To develop effective pharmaceutical formulations using supercritical carbon dioxide (scCO₂) techniques, it is necessary to obtain the solubility of the medicinal ingredients in scCO₂. In the current study, the solubility of Amantadine in scCO₂ was evaluated under 28 different operating conditions involving seven pressures and four temperatures. To theoretically study this process, some popular empirical models and two well-known thermodynamic models (PR-WS and PC-SAFT) were examined. The results suggest that the PR-WS and PC-SAFT models are the most accurate in establishing a correlation of the solubility of Amantadine in scCO₂.

中文翻译：

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使用绿色超临界处理的纳米药物制剂：实验溶解度测量和理论研究

为了利用超临界二氧化碳(scCO _{2 )技术开发有效的药物制剂，有必要获得药物成分在scCO 2}中的溶解度。在当前的研究中，在涉及七种压力和四种温度的28种不同操作条件下评估了金刚烷胺在scCO ₂中的溶解度。为了从理论上研究这个过程，研究了一些流行的经验模型和两个著名的热力学模型（PR-WS 和 PC-SAFT）。_{结果表明，PR-WS 和PC-SAFT 模型在建立金刚烷胺在scCO 2}中的溶解度相关性方面最为准确。