In response to the COVID-19 pandemic, we established and sustained local production of Alcohol-Based Hand Rub (ABHR) at a district scale for healthcare facilities and community, public locations in four districts in Uganda. District officials provided space and staff for production units. The project renovated space for production, trained staff on ABHR production, and transported ABHR to key locations. The production officer conducted internal ABHR quality assessments while trained district health inspectors conducted external quality assessments prior to distribution. Information, education, and communication materials accompanied ABHR distribution. Onsite ABHR consumption was monitored by site staff using stock cards. On average, it took 11 days (range: 8–14) and 5,760 USD (range: 4,400–7,710) to setup a production unit. From March to December 2021, 21,600 L of quality-controlled ABHR were produced for 111 healthcare facilities and community locations at an average cost of 4.30 USD/L (range: 3.50–5.76). All ABHR passed both internal and external quality control (average ethanol concentration of 80%, range: 78–81%). This case study demonstrated that establishing centralized, local production of quality-controlled, affordable ABHR at a district-wide scale is feasible and strengthens the ability of healthcare workers and community locations to access and use ABHR during infectious disease outbreaks in low-resource countries.

为了应对 COVID-19 大流行，我们在乌干达四个地区的医疗机构、社区和公共场所建立并维持了地区规模的酒精洗手液 (ABHR) 的本地生产。地区官员为生产单位提供空间和人员。该项目翻新了生产空间，对员工进行了 ABHR 生产培训，并将 ABHR 运送到了关键地点。生产官员进行了内部 ABHR 质量评估，而经过培训的地区卫生检查员则在分发前进行了外部质量评估。信息、教育和交流材料随 ABHR 一起分发。现场工作人员使用库存卡监控现场 ABHR 消耗量。平均而言，建立一个生产单元需要 11 天（范围：8–14）和 5,760 美元（范围：4,400–7,710）。从 2021 年 3 月到 12 月，为 111 个医疗机构和社区地点生产了 21,600 升质量受控的 ABHR，平均成本为 4.30 美元/升（范围：3.50-5.76）。所有 ABHR 通过内部和外部质量控制（平均乙醇浓度为 80%，范围：78–81%）。该案例研究表明，在全区范围内集中、本地生产质量受控、负担得起的 ABHR 是可行的，并且可以增强医护人员和社区地点在资源匮乏国家传染病爆发期间获取和使用 ABHR 的能力。