Background:: Two significant families of compounds i.e. 1,3,4-oxadiazole and ben-zimidazole, have undergone extensive investigation into their pharmacological characteristics and possible therapeutic applications. Both classes have shown their potential in a variety of ap-plications, and because of their synergistic interactions, they may have an even better therapeutic impact when combined. Objectives:: To produce a specific molecule with potent therapeutic properties, it is now common methods to combine at least two pharmacophores. This facilitates interaction with several targets, enhances biological functions, or eliminates adverse effects associated with them. Conclusion:: The synthesis of benzimidazole-1,3,4-oxadiazole hybrid compounds has recently involved the use of several synthetic techniques, all of which are detailed in the literature along with the advantages and disadvantages. It has been noted that the structure-activity relationship relates their pharmacological actions to their molecular structure. In order to set the stage for future research, the study aims to provide researchers with an effective toolbox and an under-standing of benzimidazole and 1,3,4-oxadiazole hybrid compounds.

中文翻译：

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苯并咪唑-恶二唑杂化物：合成、药理活性的新途径以及开发更有效配体的最新专利

背景：两个重要的化合物家族，即1,3,4-恶二唑和苯并咪唑，对其药理学特性和可能的​​治疗应用进行了广泛的研究。这两类药物都在各种应用中显示出了它们的潜力，并且由于它们的协同相互作用，它们组合起来可能会产生更好的治疗效果。目标：为了生产具有有效治疗特性的特定分子，目前常用的方法是结合至少两种药效团。这有利于与多个靶标的相互作用，增强生物功能，或消除与其相关的不利影响。结论：苯并咪唑-1,3,4-恶二唑杂化化合物的合成最近涉及多种合成技术的使用，所有这些技术及其优点和缺点在文献中都有详细介绍。已经注意到，结构-活性关系将它们的药理作用与其分子结构联系起来。为了为未来的研究奠定基础，该研究旨在为研究人员提供有效的工具箱以及对苯并咪唑和1,3,4-恶二唑杂化化合物的理解。