This study is done to evaluate the immunohistochemical expression of E-cadherin and N-cadherin in glandular odontogenic cysts (GOC), inflammatory periodontal (IPDL) cysts, and dental follicles (DF), and if there is a correlation with their biological behavior GOC, IPDL cysts, and DF cases were collected and investigated by immunohistochemistry. The area percent of immunoexpressed markers was calculated by SPSS version 25. The statistical analysis revealed a clear, statistically significant difference between the studied groups regarding the area percentage of the two immune-expression markers (p value = 0.000). The highest area percentage of the mean value of E-cadherin was recorded in IPDL cysts group with the most negligible value recorded in the group of GOC. On the other hand, the highest area percentage of the mean value of N-cadherin was documented in the group of GOC with the least recorded value was noted in the group of DF. We noted that the cadherin switch mechanism in the epithelial lining of odontogenic cysts is a critical step in the epithelial mesenchymal transition process which may associates with clinical behavior and may also impact the mode of treatment.

中文翻译：

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使用 E-钙粘蛋白和 N-钙粘蛋白对腺性牙源性囊肿和炎性牙周囊肿的潜在行为进行免疫组织化学评估

本研究旨在评估腺性牙源性囊肿 (GOC)、炎症性牙周囊肿 (IPDL) 和牙囊 (DF) 中 E-钙粘蛋白和 N-钙粘蛋白的免疫组织化学表达，以及与其生物学行为 GOC 是否存在相关性、IPDL囊肿和DF病例被收集并通过免疫组织化学进行研究。免疫表达标记物的面积百分比由 SPSS 25 版计算。统计分析显示，在两个免疫表达标记物的面积百分比方面，研究组之间存在明显的统计学显着差异（p 值 = 0.000）。IPDL囊肿组中E-钙粘蛋白平均值的面积百分比最高，GOC组中记录的值最低可忽略不计。另一方面，在GOC组中记录了N-钙粘蛋白平均值的最高面积百分比，在DF组中记录了最小记录值。我们注意到，牙源性囊肿上皮内层的钙粘蛋白转换机制是上皮间质转化过程中的关键步骤，可能与临床行为相关，也可能影响治疗模式。