Fibrils of the protein α-synuclein (Asyn) are implicated in the pathogenesis of Parkinson Disease, Lewy Body Dementia, and Multiple System Atrophy. Numerous forms of Asyn fibrils have been studied by solid-state NMR and resonance assignments have been reported. Here, we report a new set of ¹³C, ¹⁵N assignments that are unique to fibrils obtained by amplification from postmortem brain tissue of a patient diagnosed with Lewy Body Dementia.

中文翻译：

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从路易体痴呆组织扩增的 α 突触核蛋白原纤维的 13C 和 15N 共振分配

蛋白质 α-突触核蛋白 (Asyn) 的原纤维与帕金森病、路易体痴呆和多系统萎缩症的发病机制有关。通过固态核磁共振研究了多种形式的反同步原纤维，并报道了共振归属。在这里，我们报告了一组新的¹³ C、¹⁵ N 分配，这些分配是通过从诊断为路易体痴呆的患者死后脑组织中扩增获得的原纤维所特有的。