Recent research has provided evidence that metal oxide nanoparticles (NPs) have the potential to traverse the placental barrier, potentially endangering the health of both pregnant individuals and the developing fetus. The function of oxidative stress is of utmost importance in the pathophysiology of poor pregnancy outcomes. The therapeutic potential of solanesol in mitigating pregnancy complications is attributed to its robust antioxidant activity. The objective of this work was to inspect the preventative effects of solanesol on the detrimental effects generated by CuO and NiO NPs in human placental cells (BeWo). It was noticed that the exposure of BeWo cells to solanesol at concentrations ranging from 1 to 100 µg/ml for a duration of 24 h did not result in any harmful effects. However, the presence of CuO and NiO NPs led to a dose-dependent decrease in cell viability when exposed to dosages of 5 to 200 µg/ml for 24 h. It is noteworthy that solanesol significantly reduced the cytotoxicity that CuO and NiO NPs generated in BeWo cells. The data on apoptosis also demonstrated that CuO and NiO NPs have effect on the expression of the apoptotic gene caspase-3 and the decline of mitochondrial membrane potential. However, this effect was effectively reversed when solanesol was administered in combination with NPs. The findings of the mechanistic investigation indicate that the CuO and NiO NPs induced oxidative stress was notably negated when solanesol was concurrently treated. This paper presents novel findings indicating that the toxicity generated by CuO and NiO NPs in human placental cells was significantly alleviated by solanesol. Further work is necessary to explore the pharmacological potential of solanesol against nanoparticle-generated pregnancy problems.

最近的研究提供的证据表明，金属氧化物纳米粒子（NP）有可能穿过胎盘屏障，可能危及孕妇和发育中胎儿的健康。氧化应激的功能在不良妊娠结局的病理生理学中至关重要。茄尼醇在减轻妊娠并发症方面的治疗潜力归因于其强大的抗氧化活性。这项工作的目的是检查茄尼醇对 CuO 和 NiO 纳米粒子对人胎盘细胞 (BeWo) 产生的有害影响的预防作用。值得注意的是，将 BeWo 细胞暴露于浓度范围为 1 至 100 µg/ml 的茄尼醇中持续 24 小时，不会导致任何有害影响。然而，当暴露于 5 至 200 µg/ml 剂量 24 小时时，CuO 和 NiO NP 的存在会导致细胞活力呈剂量依赖性下降。值得注意的是，茄尼醇显着降低了 BeWo 细胞中 CuO 和 NiO NPs 产生的细胞毒性。细胞凋亡数据还表明，CuO和NiO NPs对凋亡基因caspase-3的表达和线粒体膜电位的下降有影响。然而，当茄尼醇与纳米颗粒联合使用时，这种效应被有效逆转。机理研究的结果表明，当同时处理茄尼醇时，CuO 和 NiO NPs 诱导的氧化应激明显被消除。本文提出的新发现表明，茄尼醇显着减轻了 CuO 和 NiO 纳米颗粒在人胎盘细胞中产生的毒性。需要进一步的工作来探索茄尼醇针对纳米颗粒引起的妊娠问题的药理学潜力。