Candida albicans is a common fungal pathogen that can cause a range of infections, from superficial mucosal infections to invasive systemic infections, particularly in individuals with immunocompromised systems. The antimicrobial potential of human secretory and excretory fluids is known; however, relatively less attention has been paid to their antifungal potential. Therefore, it is important to understand the molecular constituents and antifungal properties of human secretory and excretory fluids against human fungal pathogen C. albicans to develop new strategies for combating the disease Candidiasis and enhance our understanding of the complex interplay between the host and pathogen. In this review, we discuss the potential antifungal molecules found in human saliva, vaginal fluid, cerumen, and urine. We also discussed the potential mechanisms of action of various antimicrobial peptides found in sweat, such as dermcidin and cathelicidin, and their potential as therapeutic agents against fungal infections. We have reviewed the information on anti-candidal molecules present in cerebrospinal fluid, cerumen, lacrimal fluid, sIgA, intestinal mucous, milk, saliva, seminal fluid, sweat, urine, etc. that would be very useful in a clinical context and futuristic biotherapeutic antifungal molecules.

白色念珠菌是一种常见的真菌病原体，可引起一系列感染，从浅表粘膜感染到侵袭性全身感染，特别是在免疫系统受损的个体中。人类分泌液和排泄液的抗菌潜力是已知的；然而，对其抗真菌潜力的关注相对较少。因此，了解人类分泌液和排泄液针对人类真菌病原体白色念珠菌的分子成分和抗真菌特性对于制定对抗念珠菌病的新策略并增强我们对宿主和病原体之间复杂相互作用的理解非常重要。在这篇综述中，我们讨论了在人类唾液、阴道液、耵聍和尿液中发现的潜在抗真菌分子。我们还讨论了汗液中发现的各种抗菌肽（例如皮西丁和抗菌肽）的潜在作用机制，以及它们作为真菌感染治疗剂的潜力。我们回顾了脑脊液、耵聍、泪液、sIgA、肠粘液、牛奶、唾液、精液、汗液、尿液等中存在的抗念珠菌分子的信息，这些信息在临床背景和未来生物治疗中非常有用抗真菌分子。