Cervical cancer is the second-most prevalent gynecologic cancer in India. It is typically detected in women between the ages of 35 and 44. Cervical cancer is mainly associated with the human papillomavirus (HPV). The report shows that 70 % of cervical cancer is caused by HPV 16 and 18. There are few therapeutic options and vaccines available for cervical cancer treatment and γδ T cell therapy is one of them. This therapy can kill various types of cancers, including cervical cancer. The major γδ T cell subset is the Vγ9Vδ2 T cell, mainly distributed in peripheral blood which recognize non-MHC peptide antigens and can eliminate MHC-downregulated cancer. Moreover, γδ T cells can express different types of receptors that bind to the molecules of stressed cells, often produced on cancerous cells but absent from healthy tissue. γδ T cells possess both direct and indirect cytotoxic capabilities against malignancies and show potential antitumoral responses. However, γδ T cells also encourage the progression of cancer. Cancer immunotherapy using γδ T cells will be a potential cancer treatment, as well as cervical cancer.

This review focused on the γδ T cell and its function in cancer, with special emphasis on cervical cancer. It also focused on the ligand recognition site of γδ T cells, galectin-mediated therapy and pamidronate-treated therapy for cervical cancer. Instead of the great potential of γδ T cell for the eradication of cervical cancer, no comprehensive in-depth review is available to date, so there is a need to jot down the various roles and modes of action and different applications of γδ T cells for cancer research, which we believe will be a handy tool for the researchers and the readers.

宫颈癌是印度第二大常见的妇科癌症。通常在 35 至 44 岁的女性中检测到。宫颈癌主要与人乳头瘤病毒(HPV) 有关。报告显示，70%的宫颈癌是由HPV 16和18引起的。可用于宫颈癌治疗的治疗选择和疫苗很少，γδ T细胞疗法就是其中之一。这种疗法可以杀死多种类型的癌症，包括宫颈癌。主要的γδ T细胞亚群是Vγ9Vδ2 T细胞，主要分布在外周血中，识别非MHC肽抗原，可以消除MHC下调的癌症。此外，γδ T 细胞可以表达不同类型的受体，这些受体与应激细胞的分子结合，这些受体通常在癌细胞上产生，但在健康组织中不存在。γδ T 细胞具有针对恶性肿瘤的直接和间接细胞毒能力，并显示出潜在的抗肿瘤反应。然而，γδ T 细胞也会促进癌症的进展。使用 γδ T 细胞的癌症免疫疗法将是一种潜在的癌症治疗方法，以及宫颈癌。

本综述重点关注 γδ T 细胞及其在癌症中的功能，特别是宫颈癌。它还重点关注 γδ T 细胞的配体识别位点、半乳糖凝集素介导的疗法和帕米膦酸盐治疗宫颈癌的疗法。由于γδ T细胞在根除宫颈癌方面具有巨大的潜力，但迄今为止还没有全面深入的综述，因此有必要记下γδ T细胞的各种作用和作用方式以及不同的应用，以供将来参考。癌症研究，我们相信这将成为研究人员和读者的便利工具。