Abstract

Background:

Multiple observational studies have yielded controversial results regarding the association between Parkinson’s disease (PD) and periodontitis.

Objective:

This systematic review and meta-analysis was conducted to ascertain their bidirectional relationship.

Methods:

A literature search for relevant studies was performed in PubMed, EMBASE, the Cochrane Library, and Web of Science databases from inception to December 19, 2022. Effect sizes (ES) with 95% confidence intervals were pooled under the random-effects model. Then, leave-one-out sensitivity analysis and contour-enhanced funnel plot were applied to assess the stability of the results.

Results:

A total of 34 studies and 24 studies were included for systematic review and quantitative meta-analysis, respectively. Pooled ES indicated that periodontitis was not significantly associated with PD risk (HR = 1.13, 95% CI 0.88–1.45, n = 3; OR = 1.94, 95% CI 0.55–6.90, n = 7), while the Mendelian randomization study revealed no association between PD and periodontitis risk (coefficient [B] = –0.0001, standard error = 0.0001, p = 0.19). Furthermore, PD patients exhibited higher levels of periodontal pocket depth (SMD = 1.10, 95% CI 0.53–1.67), clinical attachment level (SMD = 1.40, 95% CI 0.55–2.26), plaque index (SMD = 0.81, 95% CI 0.22–1.39), and Oral Health Impact Profile-14 score (SMD = 0.91, 95% CI 0.33–1.49) compared to healthy controls.

Conclusions:

Our meta-analysis identified no bidirectional association between PD risk and periodontitis risk, though the prevalence of periodontitis and poorer oral status was higher in PD patients.

中文翻译：

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帕金森病和牙周炎之间有关联吗？系统回顾和荟萃分析

摘要

背景：

关于帕金森病（PD）与牙周炎之间的关联，多项观察性研究得出了有争议的结果。

客观的：

进行这项系统回顾和荟萃分析是为了确定它们的双向关系。

方法：

从成立到 2022 年 12 月 19 日，我们在 PubMed、EMBASE、Cochrane 图书馆和 Web of Science 数据库中对相关研究进行了文献检索。在随机效应模型下汇总了具有 95% 置信区间的效应量 (ES)。然后，应用留一敏感性分析和轮廓增强漏斗图来评估结果的稳定性。

结果：

总共纳入了 34 项研究和 24 项研究，分别进行系统评价和定量荟萃分析。汇总 ES 表明牙周炎与 PD 风险没有显着相关性（HR = 1.13，95% CI 0.88–1.45，n  = 3；OR = 1.94，95% CI 0.55–6.90，n  = 7），而孟德尔随机化研究显示PD 和牙周炎风险之间没有关联（系数 [B] = –0.0001，标准误差 = 0.0001，p  = 0.19）。此外，PD患者表现出较高水平的牙周袋深度（SMD = 1.10，95% CI 0.53–1.67）、临床附着水平（SMD = 1.40，95% CI 0.55–2.26）、牙菌斑指数（SMD = 0.81，95% CI） 0.22–1.39）和口腔健康影响概况-14 评分（SMD = 0.91，95% CI 0.33–1.49）与健康对照相比。

结论：

我们的荟萃分析发现，PD 风险和牙周炎风险之间没有双向关联，尽管 PD 患者中牙周炎的患病率和较差的口腔状况较高。