We first aimed to investigate resting-state functional connectivity (rs-FC) differences between adolescents exposed to SARS-CoV-2 and healthy controls. Secondly, the moderator effect of PLEs on group differences in rs-FC was examined. Thirdly, brain correlates of inflammation response during acute SARS-CoV-2 infection were investigated. Eighty-two participants aged between 14 and 24 years (SARS-CoV-2 (n = 35), controls (n = 47)) were examined using rs-fMRI. Seed-based rs-FC analysis was performed. The positive subscale of Community Assessment of Psychotic Experiences-42 (CAPE-Pos) was used to measure PLEs. The SARS-CoV-2 group had a lesser rs-FC within sensorimotor network (SMN), central executive network (CEN) and language network (LN), but an increased rs-FC within visual network (VN) compared to controls. No significant differences were detected between the groups regarding CAPE-Pos-score. However, including CAPE-Pos as a covariate, we found increased rs-FC within CEN and SN in SARS-CoV-2 compared to controls. Among the SARS-CoV-2 group, neutrophil/lymphocyte and thrombocyte*neutrophil/lymphocyte ratio was correlated with decreased/increased FC within DMN and SN, and increased FC within CEN. Our results showed rs-FC alterations within the SMN, CEN, LN, and VN among adolescents exposed to SARS-CoV-2. Moreover, changes in rs-FC associated with PLEs existed in these adolescents despite the absence of clinical changes. Furthermore, inflammation response was correlated with alterations in FC within the triple network system.

我们首先旨在调查暴露于 SARS-CoV-2 的青少年与健康对照组之间静息态功能连接 (rs-FC) 的差异。其次，检查了 PLE 对 rs-FC 组差异的调节作用。第三，研究了急性 SARS-CoV-2 感染期间大脑炎症反应的相关性。使用 rs-fMRI 对82 名年龄在 14 岁至 24 岁之间的参与者（SARS-CoV-2 ( n  = 35)，对照组 ( n  = 47)）进行了检查。进行了基于种子的 rs-FC 分析。使用社区精神病经历评估 42 (CAPE-Pos) 的正分量表来测量 PLE。与对照组相比，SARS-CoV-2 组的感觉运动网络 (SMN)、中央执行网络 (CEN) 和语言网络 (LN) 内的 rs-FC 较少，但视觉网络 (VN) 内的 rs-FC 增加。在 CAPE-Pos-score 方面，各组之间没有检测到显着差异。然而，如果将 CAPE-Pos 作为协变量，我们发现与对照组相比，SARS-CoV-2 中 CEN 和 SN 内的 rs-FC 有所增加。在 SARS-CoV-2 组中，中性粒细胞/淋巴细胞和血小板*中性粒细胞/淋巴细胞比率与 DMN 和 SN 中 FC 的降低/升高以及 CEN 中 FC 的升高相关。我们的结果显示，暴露于 SARS-CoV-2 的青少年中，SMN、CEN、LN 和 VN 内的 rs-FC 发生了变化。此外，尽管没有临床变化，但这些青少年中存在与 PLE 相关的 rs-FC 变化。此外，炎症反应与三重网络系统内 FC 的变化相关。