Individual cells are known to behave differently than their whole populations of cells. The present work focused on proteins that control cancer invasiveness. Individual Dicer siRNA knockdown of HER4, CDC42, and E-cadherin decreased MMP1 mRNA levels in SCP2, a cancer single-cell progeny that is highly metastatic to bone and adrenal gland. Individual knockdown of β-catenin, CDC42, HER3, and the γ catalytic subunit of PI3K raised MMP1 mRNA levels in SCP21, a single-cell progeny of the same tumor and patient, with low metastasis to bone and adrenal.

中文翻译：

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乳腺癌单细胞侵袭性调节剂之间的新途径

已知单个细胞的行为与其整个细胞群不同。目前的工作重点是控制癌症侵袭的蛋白质。HER4、CDC42 和 E-钙粘蛋白的个体 Dicer siRNA 敲除降低了 SCP2（一种高度转移至骨和肾上腺的癌症单细胞后代）中的 MMP1 mRNA 水平。β-连环蛋白、CDC42、HER3 和 PI3K γ 催化亚基的单独敲除提高了 SCP21 中的 MMP1 mRNA 水平，SCP21 是同一肿瘤和患者的单细胞后代，骨和肾上腺转移率较低。