Currently, several genetic variants in ERα gene (rs2234693 and rs9340799), ERβ gene (rs1256049 and rs4986938), KISS1 gene (rs4889, rs1132506 and rs5780218), LIN28B gene (rs314263, rs314276 and rs314280), and MKRN3 gene (rs2239669) have been repeatedly explored for their contribution to precocious puberty (PP) susceptibility. However, the results remain conflicting rather than conclusive. We here performed a meta-analysis to identify the real susceptibility genetic variants for PP.

中文翻译：

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一项全面的荟萃分析，以确定性早熟的易感性遗传变异

目前，ERα基因（rs2234693和rs9340799）、ERβ基因（rs1256049和rs4986938）、KISS1基因（rs4889、rs1132506和rs5780218）、LIN28B基因（rs314263、rs314276和rs314280）中存在多个遗传变异，和MKRN3基因（rs2239669）已被反复探讨它们对性早熟（PP）易感性的贡献。然而，结果仍然是相互矛盾的，而不是结论性的。我们在这里进行了一项荟萃分析，以确定 PP 的真正易感性遗传变异。