The Study for Promotion of Health in Recycling Lead (SPHERL) assessed the blood pressure (BP) and renal function (RF) responses for up to 6 years in the workers without previous occupational lead exposure. BP was the average of five consecutive readings and the estimated glomerular filtration rate was derived from serum creatinine (eGFRcrt) and cystatin C (eGFRcys). Blood lead (BL) was measured by inductively coupled plasma mass spectrometry (detection limit 0.5 μg/dL). The statistical methods included multivariable-adjusted mixed models and interval-censored Cox regression analysis. The 234 workers analyzed were on average 28.5 years old and included 91.9% men. The baseline BL concentration was 4.35 μg/dL and increased 3.17-fold over follow-up (median: 2.03 years; range: 0.92–6.45 years). The changes in BP and RF were not significantly correlated with the follow-up-to-baseline BL ratio (p ≥ .51 and p ≥ .18, respectively). The fully-adjusted changes in systolic/diastolic BP associated with a doubling of BL were −0.25/−0.12 mm Hg (CI: −0.94 to 0.44/−0.66 to 0.42 mm Hg). Accordingly, the incidence of stage-1 or -2 hypertension was not associated with the BL change (p ≥ .063). Similarly, the changes in eGFRcrt and eGFRcys associated with a 3-fold BL increment were not significant, amounting to −0.70 mL/min/1.73 m² (CI: −1.70 to 0.30 mL/min/1.73 m²) and −1.06 mL/min/1.73 m² (−2.16 to 0.03 mL/min/1.73 m²). In conclusion, the BP and RF responses to an over 3-fold BL increment were small and not significant confirming the safety of modern lead-handing facilities operating under current safety rules.

中文翻译：

---

接触铅长达六年的工人的血压和肾功能反应

回收铅促进健康研究 (SPHERL) 对以前没有职业性铅暴露的工人进行了长达 6 年的血压 (BP) 和肾功能 (RF) 反应评估。血压是五个连续读数的平均值，估计的肾小球滤过率来自血清肌酐 (eGFRcrt) 和胱抑素 C (eGFRcys)。血铅 (BL) 通过电感耦合等离子体质谱法测量（检测限 0.5 μg/dL）。统计方法包括多变量调整混合模型和区间删失Cox回归分析。接受分析的 234 名工人平均年龄为 28.5 岁，其中男性占 91.9%。基线 BL 浓度为 4.35 μg/dL，随访期间增加了 3.17 倍（中位时间：2.03 年；范围：0.92-6.45 年）。BP 和 RF 的变化与随访基线 BL 比率没有显着相关性（分别为p ≥ .51 和p ≥ .18）。与 BL 加倍相关的收缩压/舒张压的完全调整变化为−0.25/−0.12 mm Hg（CI：−0.94 至 0.44/−0.66 至 0.42 mm Hg）。因此，1 期或 -2 期高血压的发生率与 BL 变化无关 ( p ≥ .063)。同样，与 3 倍 BL 增量相关的 eGFRcrt 和 eGFRcys 变化并不显着，分别为 -0.70 mL/min/1.73 m ²（CI：-1.70 至 0.30 mL/min/1.73 m ²）和 -1.06 mL /min/1.73m ² (-2.16至0.03mL/min/1.73m ² )。总之，BP 和 RF 对超过 3 倍 BL 增量的响应很小，并且不显着确认在当前安全规则下运行的现代铅处理设施的安全性。