The residual 2,4-dichlorophenoxyacetic acid (2,4-D) in fruits poses a serious threat to human health. The continuous deposition of 2,4-D in the body may cause symptoms such as cancer or Alzheimer's disease, therefore, it is of great significance for the detection of 2,4-D traces on fruits. In this paper, we proposed a simple “paste-collect-test” strategy based on surface-enhanced Raman spectroscopy via tape sampling (SERS-tape sampling). The flexibility and stickiness of commercial tapes were combined with the excellent activity of optimized silver nanoparticles (Ag NPs) for rapid trace detection of pesticides in cherry tomatoes. The first two steps of “paste” and “collect” were completed by the tape to simplify the sampling procedure of the analyte molecules, and the “test” step was accomplished by deposing Ag NPs on the surface of the tape after analyte collection. The whole process was completed in a few minutes. The results showed that the limit of detection (LOD) of 2,4-D in cherry tomatoes was 3.63 × 10⁻¹⁰ M with the SERS-tape sampling approach, which is much lower than the maximum residue limit specified by the European Union (EU). This simple and easy-to-operate method is highly sensitive and could be a promise of 2,4-D for food safety.

中文翻译：

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通过 SERS 胶带采样快速、灵敏地检测水果表面 2,4-二氯苯氧基乙酸残留

水果中残留的2,4-二氯苯氧基乙酸（2,4-D）对人体健康构成严重威胁。2,4-D在体内持续沉积可能会引起癌症或阿尔茨海默病等症状，因此，水果上2,4-D微量的检测具有重要意义。在本文中，我们提出了一种基于通过带采样（SERS-带采样）的表面增强拉曼光谱的简单“粘贴-收集-测试”策略。商用胶带的柔韧性和粘性与优化的银纳米颗粒 (Ag NP) 的优异活性相结合，可快速痕量检测樱桃番茄中的农药。前两个步骤“粘贴”和“收集”由胶带完成，以简化分析物分子的采样程序，“测试”步骤是通过在收集分析物后将Ag NPs沉积在胶带表面来完成。整个过程在几分钟内完成。结果表明，采用SERS带采样方法，樱桃番茄中2,4-D的检出限（LOD）为3.63 × 10 ^-10  M，远低于欧盟规定的最大残留限量（欧洲联盟）。这种简单且易于操作的方法具有很高的灵敏度，可能是 2,4-D 对食品安全的承诺。