Bariatric surgery has become a recognized and effective procedure for treating obesity and type 2 diabetes (T2D). Our objective was to directly compare the caloric intake-independent effects of sleeve gastrectomy (SG) and single anastomosis duodenoileal bypass with SG (SADI-S) on glucose tolerance in rats with diet-induced obesity (DIO) and to elucidate the differences between bariatric surgery and caloric restriction.

A total of 120 adult male Wistar rats with DIO and insulin resistance were randomly assigned to surgical (sham operation, SG, and SADI-S) and dietary (pair-feeding the amount of food eaten by animals undergoing the SG or SADI-S surgeries) interventions. Body weight and food intake were weekly monitored, and 6 weeks after interventions, fasting plasma glucose, oral glucose and insulin tolerance tests, plasma insulin, adiponectin, GIP, GLP-1, and ghrelin levels were determined.

The body weight of SADI-S rats was significantly (p < 0.001) lower as compared to the sham-operated, SG, and pair-fed groups. Furthermore, SADI-S rats exhibited decreased whole body fat mass (p < 0.001), lower food efficiency rates (p < 0.001), and increased insulin sensitivity, as well as improved glucose and lipid metabolism compared to that of the SG and pair-fed rats.

SADI-S was more effective than SG, or caloric restriction, in improving glycemic control and metabolic profile, with a higher remission of insulin resistance as well as long-term weight loss.

减肥手术已成为治疗肥胖和 2 型糖尿病 (T2D) 公认且有效的手术。我们的目的是直接比较袖状胃切除术 (SG) 和 SG 十二指肠搭桥术 (SADI-S) 对饮食诱导肥胖 (DIO) 大鼠糖耐量的独立热量摄入影响，并阐明肥胖治疗之间的差异手术和热量限制。

总共 120 只患有 DIO 和胰岛素抵抗的成年雄性 Wistar 大鼠被随机分配至手术组（假手术、SG 和 SADI-S）和饮食组（配对喂养接受 SG 或 SADI-S 手术的动物所吃的食物量） ）干预。每周监测体重和食物摄入量，并在干预后 6 周测定空腹血糖、口服葡萄糖和胰岛素耐量试验、血浆胰岛素、脂联素、GIP、GLP-1 和生长素释放肽水平。

 与假手术组、SG 组和配对喂养组相比，SADI-S 大鼠的体重显着降低 ( p < 0.001)。此外，与 SG 和配对大鼠相比，SADI-S 大鼠表现出全身脂肪量减少 ( p  < 0.001)、食物效率较低 ( p  < 0.001)、胰岛素敏感性增加以及葡萄糖和脂质代谢改善。喂老鼠。

SADI-S 在改善血糖控制和代谢状况方面比 SG（热量限制）更有效，并且可以更好地缓解胰岛素抵抗并实现长期体重减轻。