Immunotherapies have thus far led to disappointing outcomes in patients suffering from glioblastoma. Published in Immunity, Chen et al.’s recent study shows the therapeutic potential of an αCTLA-4 antibody (Ab), specifically in murine mesenchymal-like glioblastoma. αCTLA-4 Ab efficacy relied on the distinctive cooperation between CD4⁺ Th1 T cells and microglia, unleashing a potent antitumor response.

中文翻译：

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结合胶质母细胞瘤的先天免疫和适应性免疫；α-CTLA-4 任务

迄今为止，免疫疗法对胶质母细胞瘤患者的治疗结果令人失望。Chen等人最近发表在《Immunity》上的研究表明了 αCTLA-4 抗体 (Ab) 的治疗潜力，特别是在小鼠间质样胶质母细胞瘤中。αCTLA-4 Ab 的功效依赖于 CD4 ⁺ Th1 T 细胞和小胶质细胞之间的独特合作，释放出有效的抗肿瘤反应。