Phleboviruses are zoonotic pathogens found in parts of Africa, Asia, Europe, and North America and cause disease symptoms ranging from self-limiting febrile illness to severe disease, including hemorrhagic diathesis, encephalitis, and ocular pathologies. There are currently no approved preventative vaccines against phlebovirus infection or antivirals for the treatment of the disease. Here, we discuss the roles of neutralizing antibodies in phlebovirus infection, the antigenic targets present on the mature polyproteins Gn and Gc, progress in vaccine development, and the prospects of identifying conserved neutralizing epitopes across multiple phleboviruses. Further research in this area will pave the way for the rational design of pan-phlebovirus vaccines that will protect against both known phleboviruses but also newly emerging phleboviruses that may have pandemic potential.

中文翻译：

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对白静脉病毒感染的体液免疫


白蛉病毒是在非洲、亚洲、欧洲和北美部分地区发现的人畜共患病原体，可引起从自限性发热性疾病到严重疾病的疾病症状，包括出血素质、脑炎和眼部病变。目前还没有批准的针对白静脉病毒感染的预防性疫苗或用于治疗该疾病的抗病毒药物。在这里，我们讨论了中和抗体在白蛉病毒感染中的作用、成熟多蛋白 Gn 和 Gc 上存在的抗原靶标、疫苗开发的进展以及鉴定多种白蛉病毒保守中和表位的前景。该领域的进一步研究将为合理设计泛静脉病毒疫苗铺平道路，该疫苗不仅可以预防已知的静脉病毒，还可以预防可能具有大流行潜力的新出现的静脉病毒。