A novel synthetic fully long-term resorbable self-gripping mesh has been recently developed to reinforce soft tissue where weakness exists during ventral hernia repair open procedures. This resorbable mesh is a macroporous, knitted, poly-L-lactide, poly-trimethylene carbonate copolymer monofilament mesh with the ProGrip™ technology, providing grips on one side of the mesh. A new poly-L-lactide, poly-trimethylene copolymer was developed to provide the required features for mechanical support during at least 20 weeks covering the critical healing period, including resistance to fatigue under cyclic loading conditions, as it occurs in patients. The yarns and mesh initial physical and biomechanical properties were characterized. Then, the mesh mechanical strength was evaluated over time. The mechanical properties of the proposed mesh were found to be above the generally recognized threshold value to mechanically support the repair site of a hernia over a 20-week period during in-vitro cyclic loading test. The mesh performance was evaluated in vivo using a published preclinical porcine model of hernia repair at 4-, 12- and 20-weeks post implantation. The burst strength of the hernia repair sites reinforced with the new mesh were higher at 4 & 12 weeks and comparable at 20 weeks to the one of the native abdominal walls. At all time points, the mesh was well tolerated with moderate inflammation and was fast integrated in the abdominal wall at 4 weeks. Particularly, the grips were nicely engulfed in the newly formed connective tissue. They must facilitate the anchoring of the mesh by their extension from the mesh and their mushroom shape. The preclinical data of the self-gripping resorbable mesh suggests that it has all the favorable characteristics for future clinical use during ventral hernia repair open procedures.

Graphical Abstract

中文翻译：

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一种新型自抓式长期可吸收网片为开放性原发性腹侧疝和切口疝提供临时支撑

最近开发出一种新型合成完全长期可吸收自抓网，用于加固腹疝修复开放手术期间存在薄弱的软组织。这种可吸收网状物是一种大孔、针织、聚-L-丙交酯、聚三亚甲基碳酸酯共聚物单丝网状物，采用 ProGrip™ 技术，在网状物的一侧提供抓握力。开发了一种新的聚左旋丙交酯、聚三亚甲基共聚物，可在至少 20 周的关键愈合期内提供机械支撑所需的功能，包括在循环负载条件下（如患者发生的情况）下的抗疲劳性。对纱线和网状物的初始物理和生物力学性能进行了表征。然后，随着时间的推移评估网的机械强度。在体外循环负载测试中，所提出的网状物的机械性能超过了普遍认可的阈值，可以在 20 周内机械支撑疝气修复部位。使用已发表的临床前猪疝气修复模型在植入后 4、12 和 20 周对网片性能进行体内评估。用新网片加固的疝气修复部位的破裂强度在第 4 周和第 12 周时更高，在第 20 周时与天然腹壁相当。在所有时间点，网片都具有良好的耐受性，具有中度炎症，并且在 4 周时快速整合到腹壁中。特别是，握把很好地被新形成的结缔组织吞没。它们必须通过从网状物的延伸和蘑菇形状来促进网状物的锚定。自抓式可吸收网片的临床前数据表明，它具有未来腹疝修复开放手术中临床使用的所有有利特性。

图形概要