The prolonged hypoxic conditions hinder chronic wounds from healing and lead to severe conditions such as delayed re-epithelialization and enhanced risk of infection. Multifunctional wound dressings are highly required to address the challenges of chronic wounds. Herein, we report polyurethane-coated sodium per carbonate-loaded chitosan hydrogel (CSPUO₂) as a multifunctional dressing. The hydrogels (Control, CSPU, and CSPUO₂) were prepared by freeze gelation method and the developed hydrogels showed high porosity, good absorption capacity, and adequate biodegradability. The release of oxygen from the CSPUO₂ hydrogel was confirmed by the increase in pH and a sustained oxygen release was observed over the period of 21 days, due to polyurethane (CSPU) coating. The CSPUO₂ hydrogel exhibited around 2-fold increased angiogenic potential in CAM assay when compared with Control and CSPU dressing. CSPUO₂ also showed good level of antibacterial efficacy against E. coli and S. aureus. In a full-thickness rat wound model, CSPUO₂ hydrogel considerably accelerated wound healing with exceptional re-epithelialization granulation tissue formation less inflammatory cells and improved skin architecture highlighting the tremendous therapeutic potential of this hydrogel when compared with control and CSPU to treat chronic diabetic and burn wounds.

中文翻译：

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具有持续释氧潜力的壳聚糖-过碳酸钠水凝胶可刺激血管生成并加速伤口愈合

长时间的缺氧条件会阻碍慢性伤口的愈合，并导致严重的情况，例如上皮再生延迟和感染风险增加。迫切需要多功能伤口敷料来应对慢性伤口的挑战。在此，我们报道了聚氨酯涂层过碳酸钠负载壳聚糖水凝胶（CSPUO ₂）作为多功能敷料。通过冷冻凝胶法制备了水凝胶（Control、CSPU和CSPUO ₂），所开发的水凝胶具有高孔隙率、良好的吸收能力和足够的生物降解性。pH 值的增加证实了CSPUO ₂水凝胶中氧气的释放，并且由于聚氨酯 (CSPU) 涂层，在 21 天的时间内观察到持续的氧气释放。与对照和 CSPU 敷料相比，CSPUO _{2水凝胶在 CAM 测定中表现出约 2 倍的血管生成潜力。}CSPUO _2对大肠杆菌和金黄色葡萄球菌也表现出良好的抗菌功效。在全层大鼠伤口模型中，CSPUO ₂水凝胶显着加速了伤口愈合，具有出色的上皮再形成、肉芽组织形成、炎症细胞减少和皮肤结构改善，突显了与对照和 CSPU 相比，该水凝胶在治疗慢性糖尿病和糖尿病方面具有巨大的治疗潜力。烧伤伤口。