: Alzheimer’s disease, a neurodegenerative disease, is a progressive and irreversible disease that has become a global challenge due to its increasing prevalence and absence of available potential therapies. Protein misfolding and aggregation are known to be the root of several protein neurodegenerative diseases, including Alzheimer’s disease. Protein aggregation is a phenomenon where misfolded proteins accumulate and clump together intra-or extracellularly. This accumulation of misfolded amyloid proteins leads to the formation of plaquesin the neuronal cells, also known as amyloid β plaques. The synthesis of amyloid β plaques and tau protein aggregation are the hallmarks of Alzheimer’s disease. Potential therapeutics must be developed in conjunction with an understanding of the possible root cause involving complex mechanisms. The development of therapeutics that can inhibit protein misfolding and aggregation, involved in the pathogenesis of Alzheimer's disease, could be one of the potential solutions to the disease.

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深入了解阿尔茨海默病中的蛋白质聚集及其抑制

：阿尔茨海默病是一种神经退行性疾病，是一种进行性且不可逆转的疾病，由于其患病率不断增加且缺乏可用的潜在疗法，已成为全球挑战。已知蛋白质错误折叠和聚集是多种蛋白质神经退行性疾病的根源，包括阿尔茨海默病。蛋白质聚集是错误折叠的蛋白质在细胞内或细胞外累积并聚集在一起的现象。错误折叠的淀粉样蛋白的积累导致神经元细胞中斑块的形成，也称为β淀粉样斑块。β 淀粉样蛋白斑块的合成和 tau 蛋白聚集是阿尔茨海默病的标志。开发潜在的治疗方法必须结合对涉及复杂机制的可能根本原因的理解。开发能够抑制参与阿尔茨海默氏病发病机制的蛋白质错误折叠和聚集的疗法可能是该疾病的潜在解决方案之一。