Biological responsiveness refers to the capacity of living organisms to adapt to changes in both their internal and external environments through physiological and behavioral mechanisms. One of the prominent aspects of aging is the decline in this responsiveness, which can lead to a deterioration in the processes required for maintenance, survival, and growth. The vital link between physiological responsiveness and the essential life processes lies within the signaling systems. To devise effective strategies for controlling the aging process, a comprehensive reevaluation of this connecting loop is imperative.

This review aims to explore the impact of aging on signaling systems responsible for responsiveness and introduce a novel perspective on intervening in the aging process by restoring the compromised responsiveness. These innovative mechanistic approaches for modulating altered responsiveness hold the potential to illuminate the development of action plans aimed at controlling the aging process and treating age-related disorders.

生物反应性是指生物体通过生理和行为机制适应内外环境变化的能力。衰老的一个突出方面是这种反应能力的下降，这可能导致维持、生存和生长所需的过程恶化。生理反应和基本生命过程之间的重要联系在于信号系统。为了制定有效的策略来控制老化过程，必须对这一连接环路进行全面的重新评估。

本综述旨在探讨衰老对负责反应能力的信号系统的影响，并提出通过恢复受损的反应能力来干预衰老过程的新视角。这些调节反应性改变的创新机制方法有可能阐明旨在控制衰老过程和治疗与年龄相关的疾病的行动计划的制定。