Mushrooms have been utilized by humans for thousands of years due to their medicinal and nutritional properties. They are a crucial natural source of bioactive secondary metabolites, and recent advancements have led to the isolation of several alkynyl-containing compounds with potential medicinal uses. Despite their relatively low abundance, naturally occurring alkynyl compounds have attracted considerable attention due to their high reactivity. Bioactivity studies have shown that alkynyl compounds exhibit significant biological and pharmacological activities, including antitumor, antibacterial, antifungal, insecticidal, phototoxic, HIV-inhibitory, and immunosuppressive properties. This review systematically compiles 213 alkynyl-containing bioactive compounds isolated from mushrooms since 1947 and summarizes their diverse biological activities, focusing mainly on cytotoxicity and anticancer effects. This review serves as a detailed and comprehensive reference for the chemical structures and bioactivity of alkynyl-containing secondary metabolites from mushrooms. Moreover, it provides theoretical support for the development of chemical constituents containing alkynyl compounds in mushrooms based on academic research and theory.

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中文翻译：

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蘑菇中的含炔基化合物及其生物活性

由于其药用和营养特性，蘑菇已被人类利用了数千年。它们是生物活性次生代谢物的重要天然来源，最近的进展已导致几种具有潜在药用用途的含炔基化合物的分离。尽管其丰度相对较低，但天然存在的炔基化合物由于其高反应性而引起了相当大的关注。生物活性研究表明，炔基化合物具有显着的生物和药理活性，包括抗肿瘤、抗菌、抗真菌、杀虫、光毒性、HIV抑制和免疫抑制特性。这篇综述系统地整理了自1947年以来从蘑菇中分离出来的213种含炔基的生物活性化合物，并总结了它们多样化的生物活性，主要关注细胞毒性和抗癌作用。该综述为蘑菇含炔基次生代谢物的化学结构和生物活性提供了详细和全面的参考。并以学术研究和理论为基础，为蘑菇中含炔基化合物化学成分的开发提供理论支撑。

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