3-acetylpyridine (3-AP) is a neurotoxin that is known to mainly affect the inferior olivary nucleus (ION) in the brain stem. Although several studies have explored the effect of this neurotoxin, still further investigation is required to understand the impact of this toxin on different parts of the brain. In this research, two groups of rats were studied, the 3-AP-treated and the control groups. Behavioral, stereological, and immunohistochemical analyses were performed. The locomotor activity of the 3-AP-treated rats decreased whereas their anxiety levels were higher than in normal controls. Also, memory performance was impaired in animals in the 3-AP group. Microscopic observations showed a decline in the numerical density of neurons in the hippocampus and striatum along with gliosis. Although this toxin is used to affect the ION, it exerts a neurotoxic effect on different brain regions.

3-乙酰吡啶 (3-AP) 是一种神经毒素，已知主要影响脑干中的下橄榄核 (ION)。尽管一些研究已经探讨了这种神经毒素的影响，但仍需要进一步研究以了解这种毒素对大脑不同部位的影响。在这项研究中，研究了两组大鼠：3-AP 治疗组和对照组。进行了行为、体视学和免疫组织化学分析。3-AP治疗组大鼠的运动能力下降，而焦虑水平却高于正常对照组。此外，3-AP 组动物的记忆能力也受到损害。显微镜观察显示，海马和纹状体中神经元的数量密度随着神经胶质细胞增生而下降。虽然这种毒素是用来影响 ION 的，但它对不同的大脑区域产生神经毒性作用。