Induction of obesity by dietary fats and oils differs according to the type of fat. Adiponectin is believed to be related to obesity prevention. We hypothesized that flaxseed oil is important for preventing obesity and producing adiponectin. To clarify this hypothesis, we investigated the relationship between obesity and different fat sources in mice fed diets with 6 types of fat and oils. C57BL/6J mice were given a control diet containing 5% corn oil or a high-fat diet containing 20% of either lard, palm oil, rapeseed oil, oleate-rich safflower oil, corn oil, or flaxseed oil for 14 weeks. In another experiment, mice were given a control diet and rosiglitazone (10 mg/kg body weight) by oral gavage for 1 week. At the end of study, plasma adiponectin and expression of fatty acid metabolism–related factors in white and brown adipose tissue and the liver were measured. Dietary flaxseed oil, which is rich in α-linolenic acid, did not induce obesity. Flaxseed oil resulted in increased β-oxidation–related factors in epididymal white adipose tissue, decreased fatty acid synthesis–related factors in the liver, and thermogenesis-related factor in brown adipose tissue following increase of plasma adiponectin. The results suggested that increase in plasma adiponectin after intake of flaxseed oil may be due to altered expression of AdipoQ and peroxisome proliferator-activated receptor γ in epididymal white adipose tissue. Flaxseed oil increased expression of adiponectin in visceral fat and regulated obesity-controlling fatty acid metabolism-related factors in white adipose tissue and liver, and thermogenesis-related factor in brown adipose tissue.

膳食脂肪和油对肥胖的诱导作用因脂肪类型而异。脂联素被认为与预防肥胖有关。我们假设亚麻籽油对于预防肥胖和产生脂联素很重要。为了阐明这一假设，我们研究了饲喂 6 种脂肪和油类饮食的小鼠的肥胖与不同脂肪来源之间的关系。C57BL/6J 小鼠接受含有 5% 玉米油的对照饮食或含有 20% 猪油、棕榈油、菜籽油、富含油酸的红花油、玉米油或亚麻籽油的高脂肪饮食，为期 14 周。在另一项实验中，小鼠接受对照饮食和罗格列酮（10 mg/kg 体重）口服灌胃 1 周。研究结束时，测量了血浆脂联素以及白色和棕色脂肪组织和肝脏中脂肪酸代谢相关因子的表达。膳食亚麻籽油富含α-亚麻酸，不会诱发肥胖。亚麻籽油导致附睾白色脂肪组织中的β-氧化相关因子增加，肝脏中脂肪酸合成相关因子减少，以及血浆脂联素增加后棕色脂肪组织中产热相关因子减少。结果表明，摄入亚麻籽油后血浆脂联素增加可能是由于附睾白色脂肪组织中AdipoQ亚麻籽油增加内脏脂肪中脂联素的表达，并调节白色脂肪组织和肝脏中控制肥胖的脂肪酸代谢相关因子以及棕色脂肪组织中的产热相关因子。