Hypertension in children with neuroblastoma is uncommon and can be difficult to control due to the potential for multiple underlying causes. We present the case of a pediatric patient with high-grade neuroblastoma which was complicated by hypertensive emergency. The patient had imaging suggestive of renal artery compression, as well as significantly elevated normetaphrine levels. Multiple anti-hypertensive agents, including an angiotensin converting enzyme inhibitor, α- and β-adrenergic receptor blockers, and a tyrosine hydroxylase inhibitor, were initiated prior to tumor excision. While her blood pressure improved during the post-operative period, she continued to require multiple antihypertensive medications due to residual tumor burden. In this report, we highlight the importance of careful, multidisciplinary management to avoid peri-operative complications in patients with catecholamine-producing tumors.

神经母细胞瘤儿童的高血压并不常见，并且由于潜在的多种潜在原因而难以控制。我们介绍了一名患有高级别神经母细胞瘤并并发高血压急症的儿科患者的病例。患者的影像学检查提示肾动脉受压，并且去甲肾上腺素水平显着升高。在肿瘤切除之前开始使用多种抗高血压药物，包括血管紧张素转换酶抑制剂、α-和β-肾上腺素能受体阻滞剂以及酪氨酸羟化酶抑制剂。虽然她的血压在术后期间有所改善，但由于残留的肿瘤负荷，她仍然需要多种抗高血压药物。在本报告中，我们强调了对产生儿茶酚胺的肿瘤患者进行仔细的多学科管理以避免围手术期并发症的重要性。