Latin American Trans-ancestry INitiative for OCD genomics (LATINO): Study protocol,American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

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Latin American Trans-ancestry INitiative for OCD genomics (LATINO): Study protocol
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics ( IF 2.8 ) Pub Date : 2023-11-09 , DOI: 10.1002/ajmg.b.32962
James J Crowley _{1,

2} , Carolina Cappi _{3,

4} , Marcos E Ochoa-Panaifo ₅ , Renee M Frederick ₆ , Minjee Kook ₆ , Andrew D Wiese ₆ , Diana Rancourt ₇ , Elizabeth G Atkinson ₈ , Paola Giusti-Rodriguez ₉ , Jacey L Anderberg ₆ , , , Jonathan S Abramowitz ₁₀ , Victor R Adorno ₁₁ , Cinthia Aguirre ₁₂ , Gilberto S Alves ₁₃ , Gustavo S Alves _{14,

15} , NaEshia Ancalade ₁ , Alejandro A Arellano Espinosa ₁₆ , Paul D Arnold ₁₇ , Daphne M Ayton ₆ , Izabela G Barbosa ₁₈ , Laura Marcela Barón Castano ₁₉ , Cynthia N Barrera ₂₀ , María Celeste Berardo ₂₁ , Dayan Berrones ₂₂ , John R Best ₂₃ , Tim B Bigdeli _{24,

25} , Christie L Burton ₂₆ , Joseph D Buxbaum ₃ , Jennifer L Callahan ₂₇ , Maria Cecília B Carneiro ₂₈ , Sandra L Cepeda ₂₉ , Evelyn Chazelle ₂₁ , Jessica M Chire ₃₀ , Macarena Churruca Munoz ₃₁ , Pamela Claisse Quiroz ₃₂ , Journa Cobite ₃₃ , Jonathan S Comer ₃₄ , Daniel L Costa ₄ , Jennifer Crosbie _{26,

35} , Victor O Cruz _{36,

37} , Guillermo Dager ₃₈ , Luisa F Daza ₁₉ , Anabel de la Rosa-Gómez ₃₉ , Daniela Del Río ₄₀ , Fernanda Z Delage ₄₁ , Carolina B Dreher _{42,

43} , Lucila Fay ₂₁ , Tomas Fazio ₂₁ , Ygor A Ferrão ₄₄ , Gabriela M Ferreira _{41,

45} , Edith G Figueroa ₄₆ , Leonardo F Fontenelle _{47,

48} , Diego A Forero ₄₉ , Daniele T H Fragoso ₄₁ , Bharathi S Gadad ₅₀ , Sheldon R Garrison ₅₁ , Andres González ₅₂ , Laura D Gonzalez ₂₁ , Marco A González ₃₉ , Polaris Gonzalez-Barrios _{53,

54} , Wayne K Goodman ₆ , Dorothy E Grice ₃ , Jerry Guintivano ₂ , Daniel G Guttfreund ₅₅ , Andrew G Guzick ₆ , Matthew W Halvorsen ₁ , Joseph D Hovey ₅₆ , Hailiang Huang ₅₇ , Jonathan Irreño-Sotomonte ₅₈ , Reinhard Janssen-Aguilar ₅₉ , Matias Jensen ₆₀ , Alexandra Z Jimenez Reynolds ₆ , Joali Alexandra Juárez Lujambio ₆₁ , Nasim Khalfe ₆₂ , Madison A Knutsen _{6,

63} , Caleb Lack ₆₄ , Nuria Lanzagorta ₆₅ , Monicke O Lima ₄ , Melanie O Longhurst ₅₀ , David A Lozada Martinez ₅ , Elba S Luna ₃₆ , Andrea H Marques ₆₆ , Molly S Martinez _{67,

68} , Maria de Los Angeles Matos ₂₁ , Caitlyn E Maye ₆ , Joseph F McGuire ₆₉ , Gabriela Menezes ₇₀ , Charlene Minaya ₇₁ , Tomás Miño ₆₀ , Sara M Mithani ₇₂ , Circe Montes de Oca ₇₃ , Alonso Morales-Rivero ₇₄ , Maria E Moreira-de-Oliveira ₇₀ , Olivia J Morris ₆ , Sandra I Muñoz ₃₉ , Zainab Naqqash ₂₃ , Ambar A Núñez Bracho ₅₂ , Belinda E Núñez Bracho ₅₂ , Maria Corina Ochoa Rojas ₁₉ , Luis A Olavarria Castaman ₅ , Trinidad Olivos Balmaceda ₇₅ , Iliana Ortega ₁₇ , Darpan I Patel ₇₂ , Ainsley K Patrick ₆₉ , Mariel Paz Y Mino _{76,

77} , Jose L Perales Orellana ₇₈ , Bárbara Perdigão Stumpf ₁₈ , Tamara Peregrina ₇₃ , Tania Pérez Duarte ₂₀ , Kelly L Piacsek ₅₁ , Maritza Placencia ₇₉ , María Belén Prieto ₂₁ , Lucas C Quarantini _{14,

80} , Yana Quarantini-Alvim _{14,

81} , Renato T Ramos _{35,

82} , Iaroslava C Ramos _{82,

83} , Vanessa R Ramos ₄ , Kesley A Ramsey ₆₉ , Elise V Ray ₁ , Margaret A Richter _{82,

84} , Bradley C Riemann ₅₁ , Juan C Rivas _{19,

85,

86,

87} , Maria C Rosario ₈₈ , Camilo J Ruggero ₂₇ , Angel A Ruiz-Chow ₇₄ , Alejandra Ruiz-Velasco ₅₀ , Melisa N Sagarnaga ₈₉ , Aline S Sampaio _{14,

15,

80} , Leonardo C Saraiva ₄ , Russell J Schachar _{26,

35} , Sophie C Schneider ₆ , Ethan J Schweissing ₆ , Laura D Seligman ₅₆ , Roseli G Shavitt ₄ , Keaton J Soileau ₆ , S Evelyn Stewart _{23,

90,

91} , Shaina B Storch ₉₂ , Emily R Strouphauer ₆₂ , Vissente Tapia Cuevas ₇₅ , Kiara R Timpano ₂₉ , Beatriz Treviño-de la Garza ₉₃ , Alexie Vallejo-Silva ₅₈ , Javier Vargas-Medrano ₅₀ , María I Vásquez ₉₄ , Guadalupe Vidal Martinez ₅₀ , Saira A Weinzimmer ₆ , Mauricio A Yanez ₆ , Gwyneth Zai _{84,

95} , Lina M Zapata-Restrepo _{87,

96,

97} , Luz M Zappa _{21,

98,

99} , Raquel M Zepeda-Burgos ₁₀₀ , Anthony W Zoghbi _{6,

101} , Euripedes C Miguel ₄ , Carolyn I Rodriguez _{102,

103} , Mayra C Martinez Mallen ₇₄ , Pablo R Moya _{31,

104} , Tania Borda _{105,

106} , María Beatriz Moyano _{21,

107,

108} , Manuel Mattheisen _{109,

110} , Stacey Pereira ₁₁₁ , Gabriel Lázaro-Muñoz _{112,

113} , Karen G Martinez-Gonzalez ₅₃ , Michele T Pato ₁₁₄ , Humberto Nicolini _{115,

116} , Eric A Storch ₆

Affiliation

Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Departamento de Psiquiatria, Universidade de São Paulo, São Paulo, São Paulo, Brazil.
Universidad Privada del Norte, Lima, Lima, Peru.
Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, USA.
Department of Psychology, University of South Florida, Tampa, Florida, USA.
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.
Department of Psychiatry, University of Florida College of Medicine, Gainesville, Florida, USA.
Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Hospital Psiquiátrico de Asunción, Direccion General, Asuncion, Central, Paraguay.
Departamento de Psiquiatría, Hospital Psiquiátrico de Asunción, Asuncion, Central, Paraguay.
Hospital Nina Rodrigues/Universidade Federal do Maranhão (UFMA), Sao Luis do Maranhao, Maranhao, Brazil.
Hospital Universitário Professor Edgard Santos, Serviço de Psiquiatria, Laboratório de Neuropsicofarmacologia-LANP, Universidade Federal da Bahia, Salvador, Bahia, Brazil.
Faculdade de Medicina da Bahia, Universidade Federal da Bahia, Pós-Graduação em Medicina e Saúde, Salvador, Bahia, Brazil.
Talk TOC, Ciudad de Mexico, Mexico.
The Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.
Departamento de Saúde Mental da Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Hospital Psiquiátrico Universitario Del Valle, Cali, Valle del Cauca, Colombia.
Centro TOC México, Ciudad de Mexico, Mexico.
Centro Interdisciplinario de Tourette, TOC, TDAH y Trastornos Asociados (CITA), Buenos Aires, Buenos Aires, Argentina.
Department of Psychology, Rice University, Houston, Texas, USA.
Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada.
Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, New York, USA.
VA New York Harbor Healthcare System, Brooklyn, New York, USA.
Department of Neurosciences and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada.
Department of Psychology, University of North Texas, Denton, Texas, USA.
Departamento de Psiquiatria e Medicina Legal, Universidade Federal do Paraná, Curitiba, Parana, Brazil.
Department of Psychology, University of Miami, Coral Gables, Florida, USA.
Instituto Nacional de Salud Mental "Honorio Delgado-Hideyo Noguchi", Dirección de Niños y Adolescentes Lima, Lima, Peru.
Universidad de Valparaíso, Instituto de Fisiología Valparaiso, Valparaiso, Chile.
Universidad Intercontinental, Ciudad de México, Ciudad de Mexico, Mexico.
Department of Counseling Psychology, University of Houston, Houston, Texas, USA.
Department of Psychology, Florida International University, Miami, Florida, USA.
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Instituto Nacional de Salud Mental "Honorio Delgado-Hideyo Noguchi", Oficina Ejecutiva de Investigación, Lima, Lima, Peru.
School of Medicine, Universidad San Martin de Porres, Lima, Lima, Peru.
Corporación Universitaria Rafael Nuñez, Cartagena, Bolivar, Colombia.
Facultad de Estudios Superiores Iztacala, Tlalnepantla de Baz, Universidad Nacional Autónoma de México, Ciudad de Mexico, Mexico.
UTOC, Ciudad de México, Ciudad de Mexico, Mexico.
Departamento de Medicina Forense e Psiquiatria, Universidade Federal do Paraná, Curitiba, Parana, Brazil.
Departamento de Psiquiatria, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Departamento de Psiquiatria, Clínica Médica, Porto Alegre, Rio Grande do Sul, Brazil.
Departamento de Psiquiatria, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil.
Hospital de Clínicas da Universidade Federal do Paraná, Curitiba, Parana, Brazil.
Departamento de Psiquiatría de Adultos, Instituto Nacional de Salud Mental "Honorio Delgado-Hideyo Noguchi", Lima, Lima, Peru.
Departamento de Psiquiatria e Medicina Legal, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
Departamento de Psiquiatria, Instituto D'Or de Pesquisa e Ensino, Rio de Janeiro, Rio de Janeiro, Brazil.
Fundación Universitaria del Área Andina, Escuela de Salud y Ciencias del Deporte, Bogota, Bogota, Colombia.
Department of Psychiatry, Texas Tech University Health Sciences Center El Paso, El Paso, Texas, USA.
Rogers Behavioral Health, Oconomowoc, Wisconsin, USA.
SIN TOC, Guadalajara, Jalisco, Mexico.
Departamento de Psiquiatría, Universidad de Puerto Rico, San Juan, Puerto Rico, USA.
Universidad de Puerto Rico Campus de Ciências Médicas, San Juan, Puerto Rico, USA.
Private Practice, San Salvador, El Salvador.
Department of Psychological Science, The University of Texas Rio Grande Valley, Edinburg, Texas, USA.
Broad Institute of MIT and Harvard, Stanley Center for Psychiatric Research, Cambridge, Massachusetts, USA.
Center for Mental Health-Cersame, School of Medicine and Health Sciences, Universidad del Rosario, Bogota, District of Colombia, Colombia.
Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suarez, Subdirección de Psiquiatría, Ciudad de México, Ciudad de Mexico, Mexico.
Centro de Neurociencias, Universidad de Valparaíso, Valparaiso, Chile.
Talk TOC, Ciudad de México, Ciudad de Mexico, Mexico.
Baylor College of Medicine, School of Medicine, Houston, Texas, USA.
Department of Psychology, Augustana College, Rock Island, Illinois, USA.
Department of Psychology, University of Central Oklahoma, Edmond, Oklahoma, USA.
Departamento de Investigación Clínica, Grupo Médico Carracci, Ciudad de México, Ciudad de Mexico, Mexico.
National Institute of Mental Heatlh (NIMH), Bethesda, Maryland, USA.
DFW OCD Treatment Specialists, Richardson, Texas, USA.
Specialists in OCD and Anxiety Recovery (SOAR), Richardson, Texas, USA.
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Programa de Ansiedade, Obsessões e Compulsões, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Department of Psychology, Fordham University, New York, New York, USA.
School of Nursing, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
México Sin Estres, Ciudad de México, Ciudad de Mexico, Mexico.
Centro Médico ABC, Ciudad de México, Ciudad de Mexico, Mexico.
Centro Interdisciplinario de Neurociencia de Valparaíso, Universidad de Valparaíso, Valparaiso, Valparaiso, Chile.
Clínica de Salud Mental USFQ, Universidad San Francisco de Quito, Quito, Pichincha, Ecuador.
Universidad San Francisco de Quito, Quito, Pichincha, Ecuador.
Universidad Tegnológica Privada de Santa Cruz (UTEPSA), Santa Cruz de la Sierra, Andres Ibañez, Bolivia.
Departamento Académico de Ciencias Dinámicas, Universidad Nacional Mayor de San Marcos, Lima, Lima, Peru.
Departamento de Neurociências e Saúde Mental, Faculdade de Medicina da Bahia, Universidade Federal da Bahia, Salvador, Bahia, Brazil.
Faculdade Santa Casa, Faculdade de Psicologia, Salvador, Bahia, Brazil.
Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Department of Psychiatry, Frederick Thompson Anxiety Disorders Centre, Toronto, Ontario, Canada.
Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Departamento de Psiquiatría, Universidad del Valle, Cali, Valle del Cauca, Colombia.
Departamento de Psiquiatria, Universidad ICESI, Cali, Valle del Cauca, Colombia.
Departamento de Psiquiatria, Fundación Valle del Lili, Cali, Valle del Cauca, Colombia.
Departamento de Psiquiatria da, Universidade Federal de São Paulo (UNIFESP), Sao Paulo, Sao Paulo, Brazil.
Facultad de Psicología, Universidad de Buenos Aires, Buenos Aires, Buenos Aires, Argentina.
BC Mental Health and Substance Use Services, Vancouver, British Columbia, Canada.
BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada.
Washington University in St. Louis, St. Louis, Missouri, USA.
Departamento de Psicología, Universidad de Monterrey, Monterrey, Nuevo Leon, Mexico.
Hospital Nacional Arzobispo Loayza, Servicio de Salud Mental, Lima, Lima, Peru.
Department of Molecular Brain Sciences, Centre for Addiction and Mental Health, Neurogenetics Section, Toronto, Ontario, Canada.
Facultad de Ciencias de la Salud, Universidad ICESI, Cali, Valle, Colombia.
Department of Neurology, Global Brain Health Institute-University of California San Francisco, San Francisco, California, USA.
Departamento de Salud Mental, Hospital de Niños Ricardo Gutierrez, Buenos Aires, Buenos Aires, Argentina.
Hospital Universitario Austral, Materno Infantil, Buenos Aires, Buenos Aires, Argentina.
Centro de Investigación en Ciencias y Humanidades, Universidad Dr. José Matías Delgado, Santa Tecla, La Libertad, El Salvador.
Department of Psychiatry, New York State Psychiatric Institute, New York, New York, USA.
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA.
Department of Psychiatry, Temerty Faculty of Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA.
Centro Interdisciplinario de Neurociencia de Valparaiso (CINV), Valparaiso, Chile.
Instituto Realize, Buenos Aires, Buenos Aires, Argentina.
Facultad de Psicología, Universidad Catolica Argentina, Buenos Aires, Buenos Aires, Argentina.
Asociación de Psiquiatras Argentinos (APSA), Buenos Aires, Buenos Aires, Argentina.
Asociación de Psiquiatras Argentinos (APSA), Presidente del Capítulo de Investigacion en Psiquiatria, Buenos Aires, Buenos Aires, Argentina.
Department of Community Health and Epidemiology & Faculty of Computer Science, Dalhousie University, Halifax, Nova Scotia, Canada.
LMU Munich, Institute of Psychiatric Phenomics and Genomics (IPPG), Munich, Germany.
Baylor College of Medicine, Center for Medical Ethics and Health Policy, Houston, Texas, USA.
Center for Bioethics, Harvard University School of Medicine, Boston, Massachusetts, USA.
Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.
Department of Psychiatry, Rutgers University-Robert Wood Johnson Medical School, Piscataway, New Jersey, USA.
Departamento de Psiquiatría, Ciudad de México, Grupo Médico Carracci, Ciudad de Mexico, Mexico.
Laboratorio de Genómica de Enfermedades Psiquiátricas y Neurodegenerativas, Ciudad de México, Instituto Nacional de Medicina Genómica, Ciudad de Mexico, Mexico.

Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder. Worldwide, its prevalence is ~2% and its etiology is mostly unknown. Identifying biological factors contributing to OCD will elucidate underlying mechanisms and might contribute to improved treatment outcomes. Genomic studies of OCD are beginning to reveal long-sought risk loci, but >95% of the cases currently in analysis are of homogenous European ancestry. If not addressed, this Eurocentric bias will result in OCD genomic findings being more accurate for individuals of European ancestry than other ancestries, thereby contributing to health disparities in potential future applications of genomics. In this study protocol paper, we describe the Latin American Trans-ancestry INitiative for OCD genomics (LATINO, https://www.latinostudy.org). LATINO is a new network of investigators from across Latin America, the United States, and Canada who have begun to collect DNA and clinical data from 5000 richly phenotyped OCD cases of Latin American ancestry in a culturally sensitive and ethical manner. In this project, we will utilize trans-ancestry genomic analyses to accelerate the identification of OCD risk loci, fine-map putative causal variants, and improve the performance of polygenic risk scores in diverse populations. We will also capitalize on rich clinical data to examine the genetics of treatment response, biologically plausible OCD subtypes, and symptom dimensions. Additionally, LATINO will help elucidate the diversity of the clinical presentations of OCD across cultures through various trainings developed and offered in collaboration with Latin American investigators. We believe this study will advance the important goal of global mental health discovery and equity.

中文翻译：

拉丁美洲跨祖先强迫症基因组学倡议 (LATINO)：研究方案

强迫症（OCD）是一种使人衰弱的精神疾病。在世界范围内，其患病率约为 2%，且其病因大多未知。识别导致强迫症的生物因素将阐明潜在的机制，并可能有助于改善治疗结果。强迫症的基因组研究开始揭示长期寻找的风险位点，但目前分析中的 95% 以上的病例具有同质欧洲血统。如果不加以解决，这种以欧洲为中心的偏见将导致强迫症基因组研究结果对于欧洲血统的个体比其他血统的个体更准确，从而导致基因组学未来潜在应用中的健康差异。在本研究方案文件中，我们描述了拉丁美洲强迫症基因组跨祖先倡议（LATINO，https://www.latinostudy.org）。LATINO 是一个由来自拉丁美洲、美国和加拿大的研究人员组成的新网络，他们已开始以文化敏感和道德的方式从 5000 名具有丰富表型的拉丁美洲血统强迫症病例中收集 DNA 和临床数据。在这个项目中，我们将利用跨祖先基因组分析来加速OCD风险位点的识别，精细绘制假定的因果变异，并提高不同人群中多基因风险评分的表现。我们还将利用丰富的临床数据来检查治疗反应的遗传学、生物学上合理的强迫症亚型和症状维度。此外，LATINO 将通过与拉丁美洲研究人员合作开发和提供的各种培训，帮助阐明跨文化强迫症临床表现的多样性。我们相信这项研究将推进全球心理健康发现和公平的重要目标。

更新日期：2023-11-10

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