Background

Gastric cancer (GC) is a common malignant tumor of the digestive tract. Claudin-5 is upregulated in GC tumor tissues, but its effect on GC is imprecise. In this study, we analyzed the influence of claudin-5 on GC.

Objectives

To investigate the effect of Claudin-5 on Gastric cancer (GC).

Results

We confirmed that the content of claudin-5 in MKN45 and AGS cells was boosted by Claudin-5 transfection, but decreased by si-Claudin-5 transfection. Besides, claudin-5 overexpression expedited GC cells proliferation, migration and invasion, but repressed GC cells apoptosis. Silencing claudin-5 curbed tumor growth in vivo.

Conclusion

Claudin-5 overexpression expedited GC cells proliferation, migration and invasion, but repressed GC cells apoptosis.

中文翻译：

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Claudin-5 过表达与胃癌的增殖和迁移相关

背景

胃癌（GC）是消化道常见的恶性肿瘤。Claudin-5 在 GC 肿瘤组织中表达上调，但其对 GC 的影响并不精确。在本研究中，我们分析了claudin-5对GC的影响。

目标

探讨Claudin-5对胃癌（GC）的影响。

结果

我们证实，MKN45和AGS细胞中claudin-5的含量因Claudin-5转染而增加，但因si-Claudin-5转染而降低。此外，claudin-5过表达可加速GC细胞增殖、迁移和侵袭，但抑制GC细胞凋亡。沉默claudin-5可抑制体内肿瘤生长。

结论

Claudin-5过表达加速GC细胞增殖、迁移和侵袭，但抑制GC细胞凋亡。