We examined whether cognitive reserve moderated the relationship between neurodegeneration and cognition in 67 postmortem persons with HIV (PWH) who were cognitively assessed within 1 year of death. Cognitive reserve was measured via the Wide Range Achievement Test-4 reading subtest (WRAT4). Synaptodendritic neurodegeneration was based on densities of synaptophysin and microtubule-associated protein 2 immunohistochemical reactivity in frontal cortex, and categorized as minimal, moderate, or severe (tertile-split). T-Scores from 15 cognitive tests were averaged into a global cognitive T-score. Among those with low cognitive reserve (based on WRAT4 median split), the moderate neurodegeneration group showed cognition that was poorer than the minimal neurodegeneration group and comparable to the severe neurodegeneration group. Among those with high cognitive reserve, the moderate neurodegeneration group showed cognition comparable to the minimal neurodegeneration group and better than the severe neurodegeneration group. High cognitive reserve may buffer against cognitive impairment among PWH with moderate, but not severe, neurodegeneration.

我们检查了 67 名死后 HIV 感染者 (PWH) 的认知储备是否调节了神经退行性疾病和认知之间的关系，这些人在死亡后 1 年内接受了认知评估。认知储备通过宽范围成就测试 4 阅读子测试 (WRAT4) 进行测量。突触树突神经变性基于额叶皮质中突触素和微管相关蛋白 2 免疫组织化学反应的密度，分为轻微、中度或严重（三分位分裂）。15 项认知测试的 T 分数被平均为全局认知 T 分数。在认知储备低的人中（基于 WRAT4 中值分割），中度神经变性组的认知能力比轻度神经变性组差，与重度神经变性组相当。在认知储备高的人中，中度神经变性组的认知能力与轻度神经变性组相当，但优于重度神经变性组。高认知储备可能会缓冲患有中度但不严重神经变性的感染者的认知障碍。