NGLY1, a cytoplasmic de-N-glycosylating enzyme is well conserved among eukaryotes. This enzyme has attracted considerable attention after mutations on the NGLY1 gene were found to cause a rare genetic disorder called NGLY1 deficiency. Recent explosive progress in NGLY1 research has revealed multi-functional aspects of this protein.

中文翻译：

---

NGLY1：一种迷人的多功能分子

NGLY1 是一种细胞质去N-糖基化酶，在真核生物中非常保守。在发现NGLY1基因突变会导致一种罕见的遗传性疾病（称为 NGLY1 缺乏症）后，这种酶引起了广泛关注。NGLY1 研究的最新爆炸性进展揭示了该蛋白质的多功能方面。