This review is a summarized study on CAD, CVD, atherosclerosis, and its association with the ABCA1 gene. Only 13 clinical as well as epidemiological and peer-reviewed research papers published in the associated field were chosen for the review from out of 55 articles. The research papers have been collected and studied from PubMed, Research Gate, and Google Scholar search engines. In the study, it has been found that GWAS, cell culture, and data-based studies were done to figure out the relationship of the ABCA1 gene with heart diseases. Blood samples were collected and diagnosed both biochemically and genetically to find out the lipid level and its functioning in the efflux of cholesterol and its effect and association with the ABCA1 gene, and with CAD researchers. Dysregulation of DNA methylation can be re-expressed epigenetically. These studies of the ABCA1 gene and its polymorphic variants would help in future research studies and further can develop new drugs and methods the for treatment of heart disease and CAD.

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ABCA1 基因与冠状动脉疾病 (CAD) 的关联：概述

本综述是对 CAD、CVD、动脉粥样硬化及其与 ABCA1 基因关联的研究总结。从 55 篇文章中，仅选择了 13 篇在相关领域发表的临床、流行病学和同行评审的研究论文进行评审。研究论文已从 PubMed、Research Gate 和 Google Scholar 搜索引擎收集和研究。研究发现，通过GWAS、细胞培养和基于数据的研究，弄清楚了ABCA1基因与心脏病的关系。收集血液样本并进行生化和遗传学诊断，以查明脂质水平及其在胆固醇流出中的功能及其与 ABCA1 基因的影响以及与 CAD 研究人员的关联。DNA 甲基化失调可以通过表观遗传学重新表达。这些对 ABCA1 基因及其多态性变异的研究将有助于未来的研究，并进一步开发治疗心脏病和 CAD 的新药物和方法。