Introduction: Racial and ethnic differences in pulmonary embolism (PE) mortality within rural and urban regions in the U.S. have not previously been described. PE mortality may vary across regions and urbanization given disparities in social and structural determinants and comorbid disease. Methods: Using surveillance data from the Centers for Disease Control and Prevention, age-adjusted mortality rates (AAMR) related to PE were calculated for rural and urban regions in the U.S., in non-Hispanic Black and White women and men, between 1999 and 2020. Results: Among 137,946 deaths in urban regions and 41,333 deaths in rural regions due to PE during this period, AAMR decreased 1.8% per year in urban regions from 3.1 to 100,000 in 1999 to 2.2 per 100,000 in 2020, and decreased 1% per year in rural regions from 4.3 to 100,000 in 1999 to 3.3 per 100,000 in 2020. Since 2008, AAMR from PE increased in non-Hispanic White males in rural and urban regions, decreased in non-Hispanic Black females in rural regions, and otherwise remained stagnant in all other race-sex groups. Conclusions: AAMR from PE was higher in rural compared with urban individuals, with differences by race and sex. Mortality rates remained stagnant over the last decade in non-Hispanic Black adults and non-Hispanic White females and increased in non-Hispanic White males.

简介：以前从未描述过美国农村和城市地区肺栓塞 (PE) 死亡率的种族和民族差异。鉴于社会和结构性决定因素以及共病疾病的差异，PE 死亡率可能因地区和城市化程度而异。方法：利用疾病控制和预防中心的监测数据，计算了 1999 年至 1999 年间美国农村和城市地区非西班牙裔黑人和白人女性和男性与 PE 相关的年龄调整死亡率 (AAMR)。 2020 年结果：在此期间，城市地区有 137,946 例肺栓塞死亡，农村地区有 41,333 例肺栓塞死亡，城市地区的 AMR 每年下降 1.8%，从 1999 年的每 10 万人中 3.1 例至 10 万人下降到 2020 年的每 10 万人中 2.2 例，并且每年下降 1%。农村地区每年从 1999 年的每 10 万人中 4.3 人增加到 2020 年的每 10 万人中 3.3 人。自 2008 年以来，农村和城市地区的非西班牙裔白人男性中体育运动的 AAMR 有所增加，农村地区非西班牙裔黑人女性中的 AAMR 有所下降，其他方面则保持不变在所有其他种族性别群体中都停滞不前。结论：与城市个体相比，农村个体的体育运动 AAMR 较高，且存在种族和性别差异。过去十年中，非西班牙裔黑人成年人和非西班牙裔白人女性的死亡率保持停滞，而非西班牙裔白人男性的死亡率则有所上升。