BACKGROUND Sexual and/or gender minority (SGM) individuals experience higher rates and greater severity of depressive disorders than non-SGM persons. SGM individuals are more likely than non-SGM individuals to seek mental health treatment and to present to treatment with unique characteristics that should be accounted for when considering treatment recommendations. Patients seeking care for treatment-resistant depression (TRD) are offered a variety of evidence-based interventions ranging in modality and invasiveness (eg, psychotherapy and neuromodulation). METHODS The current study used data from a TRD clinical research program to examine whether SGM (N = 52) and non-SGM (N = 202) patients differed in their clinical presentations and the treatment recommendations offered to them. RESULTS We found that SGM patients were younger, had a more severe history of childhood trauma, and reported greater current suicidality than non-SGM patients. There were no significant differences in treatment recommendations between groups. CONCLUSIONS This study adds to nascent literature investigating clinical characteristics of SGM populations seeking mental health care and provides foundational evidence for the unique treatment considerations necessary for SGM individuals seeking treatment for TRD. Research into whether treatment outcomes differ for SGM and non-SGM individuals with TRD is encouraged, given clinical differences in trauma history and suicidality.

中文翻译：

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不同性取向和性别认同的难治性抑郁症患者的临床表现存在差异。

背景技术性和/或性别少数（SGM）个体比非 SGM 个体经历更高的抑郁症发病率和更严重的程度。SGM 个体比非 SGM 个体更有可能寻求心理健康治疗，并在考虑治疗建议时应考虑到具有独特特征的治疗。寻求治疗难治性抑郁症（TRD）的患者可以获得各种循证干预措施，包括形式和侵入性（例如心理治疗和神经调节）。方法 本研究使用 TRD 临床研究计划的数据来检查 SGM (N = 52) 和非 SGM (N = 202) 患者的临床表现和向他们提供的治疗建议是否存在差异。结果 我们发现，与非 SGM 患者相比，SGM 患者更年轻，有更严重的童年创伤史，并且目前有更高的自杀倾向。各组之间的治疗建议没有显着差异。结论 这项研究补充了调查寻求心理保健的 SGM 人群临床特征的新兴文献，并为寻求 TRD 治疗的 SGM 人群所需的独特治疗考虑因素提供了基础证据。鉴于创伤史和自杀倾向的临床差异，鼓励研究患有 TRD 的 SGM 和非 SGM 个体的治疗结果是否不同。