The exposure to either medical sources or accidental radiation can cause varying degrees of radiation injury (RI). RI is a common disease involving multiple human body parts and•organs, yet effective treatments are currently limited. Accumulating evidence suggests gut microbiota are closely associated with the development and prevention of various RI. This article summarizes ten common types of RI and their possible mechanisms. It also highlights the changes and potential microbiota-based treatments for RI, including probiotics, metabolites, and microbiota transplantation. Additionally, a 5P-Framework is proposed to provide a comprehensive strategy for managing RI.

中文翻译：

---

放射损伤和基于肠道微生物群的治疗。

暴露于医疗源或意外辐射可能会导致不同程度的辐射损伤 (RI)。RI是一种常见疾病，涉及人体多个部位和器官，但目前有效的治疗方法有限。越来越多的证据表明肠道微生物群与各种 RI 的发生和预防密切相关。本文总结了十种常见的 RI 类型及其可能的机制。它还强调了 RI 的变化和潜在的基于微生物群的治疗方法，包括益生菌、代谢物和微生物群移植。此外，还提出了 5P 框架来提供管理 RI 的综合策略。