STUDY OBJECTIVES The relationship between time-limited eating (TLE) and sleep quality is a topic of growing interest in the field of chronobiology. Data in adult cohorts shows that TLE may improve sleep quality, but this has not been evaluated in adolescents. The aim of this secondary analysis was to (1) examine the impact of 8-hour TLE on sleep parameters in youth with obesity and (2) explore if there was any association between sleep patterns and glycemic profiles. METHODS Adolescents with obesity were randomized into one of three groups: 8-hour TLE (participants self-selected their eating window) + real-time continuous glucose monitor, 8-hour TLE + blinded continuous glucose monitor, or a prolonged eating window. In the primary analysis, it was found that participants in the real-time continuous glucose monitor group + 8-hour TLE group did not access their continuous glucose monitor data and thus for this analysis the two TLE groups were combined and only completers who had available Pittsburgh Sleep Quality Index (PSQI) data at all three time points were included. Participants completed the PSQI at baseline, week 4, and week 12. Mixed-effects generalized linear regression models were utilized to examine the change in PSQI score and assess association between glycemic variability and PSQI total score overtime by intervention arm. RESULTS The median PSQI total score for the TLE groups (n = 27) was 6 at week 0 (interquartile range = 5 to 10) and 5 at week 12 (interquartile range = 2 to 7). There was no significant difference in the change in total PSQI score or sleep latency between TLE and control over the study period (P > .05). There was no association between PSQI score and change in weight or glycemic profile between groups (all P values > 0.05). CONCLUSIONS These results suggest that in adolescents with obesity, an 8-hour TLE approach did not negatively impact sleep quality or efficiency when compared to a prolonged eating window. The potential effects of TLE on sleep should be further investigated in larger randomized trials. CITATION Jayakumr A, Gillett ES, Wee CP, Kim A, Vidmar AP. Impact of 8-hour time-limited eating on sleep in adolescents with obesity. J Clin Sleep Med. 2023;19(11):1941-1949.

中文翻译：

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8小时限时进食对肥胖青少年睡眠的影响。

研究目标 限时饮食 (TLE) 和睡眠质量之间的关系是时间生物学领域越来越受关注的话题。成人队列的数据表明，TLE 可以改善睡眠质量，但尚未在青少年中进行评估。这项二次分析的目的是 (1) 检查 8 小时 TLE 对肥胖青少年睡眠参数的影响，以及 (2) 探讨睡眠模式和血糖曲线之间是否存在任何关联。方法 肥胖青少年被随机分为三组之一：8 小时 TLE（参与者自行选择进食窗口）+ 实时连续血糖监测仪、8 小时 TLE + 盲法连续血糖监测仪或延长进食窗口。在主要分析中，发现实时连续血糖监测组 + 8 小时 TLE 组的参与者没有访问他们的连续血糖监测数据，因此在本次分析中，将两个 TLE 组合并在一起，并且只有完成者可以获得可用的数据包括所有三个时间点的匹兹堡睡眠质量指数 (PSQI) 数据。参与者在基线、第 4 周和第 12 周完成了 PSQI。利用混合效应广义线性回归模型来检查 PSQI 评分的变化，并评估干预组随时间推移的血糖变异性与 PSQI 总分之间的关​​联。结果 TLE 组 (n = 27) 的 PSQI 总分中位数在第 0 周为 6（四分位距 = 5 至 10），在第 12 周为 5（四分位距 = 2 至 7）。在研究期间，TLE 和对照组之间的总 PSQI 评分或睡眠潜伏期的变化没有显着差异 (P > .05)。组间 PSQI 评分与体重或血糖变化之间没有关联（所有 P 值 > 0.05）。结论 这些结果表明，在肥胖青少年中，与延长进食时间相比，8 小时 TLE 方法不会对睡眠质量或效率产生负面影响。TLE 对睡眠的潜在影响应该在更大规模的随机试验中进一步研究。奖状 Jayakumr A、Gillett ES、Wee CP、Kim A、Vidmar AP。8小时限时进食对肥胖青少年睡眠的影响。J 临床睡眠医学杂志。2023；19(11)：1941-1949。