Empirical scaling factor for predicting human pharmacokinetic profiles of disproportionate metabolites using the Css–MRTpo method and chimeric mice with humanised livers,Xenobiotica

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Empirical scaling factor for predicting human pharmacokinetic profiles of disproportionate metabolites using the Css–MRTpo method and chimeric mice with humanised livers
Xenobiotica ( IF 1.8 ) Pub Date : 2023-11-26 , DOI: 10.1080/00498254.2023.2280785
Hidetaka Kamimura ₁ , Shotaro Uehara ₁ , Nao Yoneda ₁ , Hiroshi Suemizu ₁

Affiliation

Predicting plasma concentration–time profiles of disproportionate metabolites in humans is crucial for evaluating metabolites according to the Safety Testing guidelines. We evaluated Css–MRTpo, an ...

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