OBJECTIVE The aim of this study was to determine the prevalence of low scores on eight commonly used neuropsychological tests to evaluate learning and memory, language, and executive functions in individuals with coca paste use disorders (CPUD) and to identify the differences with respect to a group of healthy nonconsuming subjects (HCs). METHODS 162 Colombian adults with CPUD and a group of 162 Colombian adult HCs participated in this comparative study. Eight tests (eighteen test scores) were grouped into three categories: learning and memory, language, and executive functions. Each participant was categorized based on the number of low scoring tests in specific percentile cut-off groups (25th, 16th, 10th, 5th, and 2nd). RESULTS In the learning and memory domain, 89.5% of individuals with CPUD and 55.6% of HCs scored below the 25th percentile on at least one of the five test scores, in the language domain, 80.7% of individuals with CPUD and 58% of HCs and in the executive function domain, 92% of individuals with CPUD and 67.3% of HCs. Having two or more scores below the 10th percentile or 10 or more at the 5th percentile shows an optimal cut-off for determining the sensitivity and specificity for discriminating between the two groups. CONCLUSIONS The individuals with CPUD had a higher percentage of low scores than the HCs in the domains of learning and memory, language, and executive function. It is important for clinicians to be aware of low scores in individuals with CPUD to avoid false-positive diagnoses of cognitive impairment.

中文翻译：

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古柯酱使用障碍患者神经心理学测试低分的多变量基本率。

目的 本研究的目的是确定八种常用神经心理学测试中低分的普遍情况，以评估古柯糊使用障碍 (CPUD) 个体的学习和记忆、语言和执行功能，并确定与一组健康的非消费对象（HC）。方法 162 名患有 CPUD 的哥伦比亚成年人和一组 162 名哥伦比亚成年 HC 参与了这项比较研究。八项测试（十八个测试分数）分为三类：学习和记忆、语言和执行功能。每个参与者根据特定百分位数截止组（第 25、第 16、第 10、第 5 和第 2）中低分测试的数量进行分类。结果 在学习和记忆领域，89.5% 的 CPUD 个体和 55.6% 的 HC 在五项测试分数中的至少一项上得分低于 25%；在语言领域，80.7% 的 CPUD 个体和 58% 的 HC在执行功能领域，92% 的人患有 CPUD，67.3% 的人患有 HC。低于第 10 个百分位数的两个或多个分数或低于第 5 个百分位数的 10 个或更多分数显示了确定区分两组的敏感性和特异性的最佳截止值。结论 在学习和记忆、语言和执行功能方面，CPUD 个体的低分比例高于 HC。对于临床医生来说，了解 CPUD 患者的低分情况很重要，以避免认知障碍的假阳性诊断。