Increasing prevalence of morbid obesity accompanied by comorbidities like type 2 diabetes mellitus (T2DM) led to a demand for improving therapeutic strategies and pharmacological intervention options. Apart from genetics, inflammation processes have been hypothesized to be of importance for the development of obesity and related aspects like insulin resistance. Within this review, we provide an overview of the intricate interplay between chronic inflammation of the adipose tissue and the hypothalamus and the development of obesity. Further understanding of this relationship might improve the understanding of the underlying mechanism and may be of relevance for the establishment of new treatment strategies.

中文翻译：

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慢性炎症与肥胖发展的相关性和后果

伴随 2 型糖尿病 (T2DM) 等合并症的病态肥胖患病率不断增加，导致需要改进治疗策略和药物干预方案。除了遗传学之外，炎症过程也被认为对于肥胖和胰岛素抵抗等相关方面的发展也很重要。在这篇综述中，我们概述了脂肪组织和下丘脑的慢性炎症与肥胖发展之间复杂的相互作用。进一步了解这种关系可能会增进对潜在机制的理解，并可能与建立新的治疗策略相关。