Long non-coding RNAs (lncRNAs) have been recently considered as one of the regulatory mechanisms of the nervous system. Hence, lncRNAs may be considered diagnostic biomarkers for bipolar disorder (BD). We aimed to investigate the expression of RMRP, CTC-487M23.5, and DGCR5 lncRNAs in bipolar patients. The levels of these three lncRNAs were measured in peripheral blood mononuclear cells (PBMCs) of 50 BD patients and 50 healthy subjects by real-time PCR. Moreover, we performed a ROC curve analysis between the gene expression and some clinical features of BD patients. Significant upregulation of RMRP and CTC-487M23.5 and no significant change in levels of DGCR5 was observed in BD individuals compared with controls. Also, we found upregulation of RMRP and downregulation of CTC-487M23.5 and DGCR5 in females with BD. The areas under the ROC curve (AUC) for RMRP and CTC-487M23.5 lncRNAs were 0.80 and 0.61, respectively. There was no significant correlation between the expression of these three lncRNAs and clinical features in PBMCs of BD patients. These results suggest a role for RMRP and CTC-487M23.5 in the pathogenesis of bipolar disorder. Moreover, the peripheral expression of these two lncRNAs might be beneficial as potential biomarkers for BD.

长非编码RNA（lncRNA）最近被认为是神经系统的调节机制之一。因此，lncRNA 可被视为双相情感障碍 (BD) 的诊断生物标志物。我们的目的是研究双相情感障碍患者中 RMRP、CTC-487M23.5 和DGCR5 lncRNA的表达。通过实时 PCR 测量了 50 名 BD 患者和 50 名健康受试者的外周血单核细胞 (PBMC) 中这三种 lncRNA 的水平。此外，我们对BD患者的基因表达和一些临床特征进行了ROC曲线分析。与对照组相比，BD 个体中RMRP和CTC-487M23.5显着上调，而DGCR5水平没有显着变化。此外，我们发现女性 BD 患者中RMRP上调， CTC-487M23.5和 DGCR5下调。RMRP和CTC-487M23.5 lncRNA的 ROC 曲线下面积 (AUC)分别为 0.80 和 0.61。BD患者PBMCs中这3种lncRNA的表达与临床特征无显着相关性。这些结果表明RMRP和CTC-487M23.5在双相情感障碍的发病机制中发挥作用。此外，这两种 lncRNA 的外周表达可能有利于作为 BD 的潜在生物标志物。