Leptospirosis is a bacterial zoonosis with a wide spectrum of clinical presentations. In order to identify potential risk factors and predictors of disease severity, a meta-analysis of the clinical features of severe and non-severe leptospirosis patients was conducted. PubMed was searched to collect studies on the difference in clinical characteristics of severe and nonsevere patients, and data were analyzed using Comprehensive Meta-Analysis V3 software. Results showed that patients with severe outcomes were more likely to have dyspnoea, oliguria, and hemorrhagic symptoms than nonsevere patients. Determining these predictors in the early stages of the disease could thus significantly reduce the development of severe cases and related mortality.

中文翻译：

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识别钩端螺旋体病的危险因素和疾病严重程度：临床预测因子的荟萃分析。

钩端螺旋体病是一种细菌性人畜共患病，具有多种临床表现。为了确定潜在的危险因素和疾病严重程度的预测因素，对重症和非重症钩端螺旋体病患者的临床特征进行了荟萃分析。检索PubMed收集重症和非重症患者临床特征差异的研究，并使用Comfortable Meta-Analysis V3软件对数据进行分析。结果显示，严重后果的患者比非严重患者更容易出现呼吸困难、少尿和出血症状。因此，在疾病的早期阶段确定这些预测因素可以显着减少重症病例的发展和相关死亡率。