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Development of practical techniques for simultaneous detection and distinction of current and emerging SARS-CoV-2 variants.
Analytical Sciences ( IF 1.6 ) Pub Date : 2023-07-30 , DOI: 10.1007/s44211-023-00396-4
Tuocen Fan 1 , Chengjie Li 1 , Xinlei Liu 1 , Hongda Xu 1 , Wenhao Li 1 , Minghao Wang 1 , Xifan Mei 1 , Dan Li 1, 2
Affiliation  

Countless individuals have fallen victim to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and have generated antibodies, reducing the risk of secondary infection in the short term. However, with the emergence of mutated strains, the probability of subsequent infections remains high. Consequently, the demand for simple and accessible methods for distinguishing between different variants is soaring. Although monitoring viral gene sequencing is an effective approach for differentiating between various types of SARS-CoV-2 variants, it may not be easily accessible to the general public. In this article, we provide an overview of the reported techniques that use combined approaches and adaptable testing methods that use editable recognition receptors for simultaneous detection and distinction of current and emerging SARS-CoV-2 variants. These techniques employ straightforward detection strategies, including tests capable of simultaneously identifying and differentiating between different variants. Furthermore, we recommend advancing the development of uncomplicated protocols for distinguishing between current and emerging variants. Additionally, we propose further development of facile protocols for the differentiation of existing and emerging variants.

中文翻译:

开发同时检测和区分当前和新出现的 SARS-CoV-2 变体的实用技术。

无数人感染了严重急性呼吸综合征冠状病毒2(SARS-CoV-2),并产生了抗体,短期内降低了继发感染的风险。但随着变异毒株的出现,后续感染的概率仍然很高。因此,对区分不同变体的简单且易于使用的方法的需求正在飙升。尽管监测病毒基因测序是区分各种类型 SARS-CoV-2 变体的有效方法,但普通公众可能不容易获得。在本文中,我们概述了已报道的技术,这些技术使用组合方法和适应性测试方法,使用可编辑识别受体来同时检测和区分当前和新出现的 SARS-CoV-2 变体。这些技术采用简单的检测策略,包括能够同时识别和区分不同变体的测试。此外,我们建议推进简单协议的开发,以区分当前和新兴的变体。此外,我们建议进一步开发简单的协议来区分现有和新兴的变体。
更新日期:2023-07-30
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