Objectives

Physical and cognitive function are two of the most important patient-reported outcomes. In oncology patients receiving chemotherapy (N = 1331), purposes were to identify subgroups of patients with distinct joint physical and cognitive function profiles and evaluate for differences in demographic and clinical characteristics, severity of common symptoms, and quality of life outcomes.

Data Sources

Measures of physical and cognitive functions were obtained six times over two cycles of chemotherapy. All of the other measures were done prior to the second or third cycle of chemotherapy. Latent profile analysis was done to identify the distinct joint physical and cognitive function profiles. Differences among the profiles were evaluated using parametric and nonparametric tests.

Conclusion

Five distinct profiles were identified (ie, Very Low Physical and Low Cognitive Function [18.4%; Both Low], Low Physical and High Cognitive Function [19.8%], Moderate Physical and Low Cognitive Function [26.7%], Changing Physical and Cognitive Function [5.4%], and Normal Physical and Cognitive Function [29.7%]). Patients in the Both Low class had the highest symptom burden and the poorest quality of life. Over 70% of the sample had moderate to severe decrements in one or both of these extremely important patient outcomes.

Implications for Nursing Practice

Clinicians need to assess for both physical and cognitive function using simple subjective and objective measures.

中文翻译：

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身体和认知功能的下降与肿瘤患者较高的症状负担相关

目标

身体和认知功能是患者报告的两个最重要的结果。在接受化疗的肿瘤患者 (N = 1331) 中，目的是确定具有不同关节身体和认知功能特征的患者亚组，并评估人口和临床特征、常见症状严重程度和生活质量结果的差异。

数据源

在两个化疗周期内进行六次身体和认知功能测量。所有其他措施均在第二或第三周期化疗之前完成。进行潜在特征分析以识别不同的关节物理和认知功能特征。使用参数和非参数测试评估配置文件之间的差异。

结论

确定了五种不同的特征（即，身体和认知功能极低[18.4%；均低]、身体和认知功能低下[19.8%]、身体和认知功能中等[26.7%]、身体和认知功能改变[5.4%]，以及正常的身体和认知功能 [29.7%]）。低等级患者的症状负担最高，生活质量最差。超过 70% 的样本在一项或两项极其重要的患者结局中出现中度至重度下降。

对护理实践的影响

临床医生需要使用简单的主观和客观测量来评估身体和认知功能。