Keap1 is associated with cytoprotective signaling. These roles of Keap1 typically focus on its role as a degrader of the antioxidant response (AR) transcription factor, Nrf2, and the inhibition of this process upon Keap1 labeling by electrophiles. However, work from several laboratories has reemphasized both the important role of Nrf2 binding in negatively regulating AR, and the fact that electrophile Keap1 modification dissociates Nrf2 from Keap1. This model appears to be applicable to other signaling modes regulated by Keap1. Here, we use recent data we have derived using experiments in zebrafish and cultured cells to discuss different models of Keap1 regulation.

中文翻译：

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将其保留在家族中：如何在 Keap1 介导的细胞信号传导中找出新范式

Keap1 与细胞保护信号传导相关。Keap1 的这些作用通常集中于其作为抗氧化反应 (AR) 转录因子 Nrf2 降解剂的作用，以及亲电子试剂标记 Keap1 时对该过程的抑制作用。然而，多个实验室的工作再次强调了 Nrf2 结合在负向调节 AR 中的重要作用，以及亲电试剂 Keap1 修饰使 Nrf2 与 Keap1 分离的事实。该模型似乎适用于 Keap1 调节的其他信号模式。在这里，我们使用通过斑马鱼和培养细胞实验获得的最新数据来讨论 Keap1 调节的不同模型。