Depression is a common psychiatric disorder that negatively affects mood and thoughts. Association studies of OXTR polymorphisms with depression have been performed repeatedly. However, the results of these studies were inconsistent. The aim of the present study was to perform a meta-analysis of case–control studies that have investigated the relationship between the OXTR polymorphism (rs53576) and depression risk. Four databases, PubMed, ScienceDirect, Springer Link, and Google Scholar, were searched, and a total of 10 studies were involved in the meta-analysis. ReviewManager (RevMan) 5.4 software was used to perform a meta-analysis of the eligible studies. A significant association between OXTR rs53576 and depression was found in the recessive model (Odds Ratio (OR) AA vs. AG + GG = 1.28, 95% Confidence Interval (CI) [1.02–1.59], P = 0.03), while there was no association with the other two genetic models (dominant model: OR AA + AG vs. GG = 1.01, 95% CI [0.87–1.18], P = 0.87; allelic model: OR A vs. G = 0.95, 95% CI [0.83–1.09], P = 0.46). A significant association was observed in the Caucasian populations (OR 1.29, 95% CI [1.01, 1.64], P = 0.04), while the Asian populations showed no significant association (OR 1.22, 95% CI [0.71, 2.09], P = 0.48). This meta-analysis is to date the first to provide a comprehensive investigation of the association of the OXTR rs53576 polymorphism with depression, and its results reflect the data currently available from the literature and can serve as a guide for further research.

中文翻译：

---

OXTR 多态性 (rs53576) 与抑郁症的关联：荟萃分析

抑郁症是一种常见的精神疾病，会对情绪和思想产生负面影响。OXTR 多态性与抑郁症的关联研究已被反复进行。然而，这些研究的结果并不一致。本研究的目的是对病例对照研究进行荟萃分析，这些研究调查了 OXTR 多态性 (rs53576) 与抑郁风险之间的关系。检索了 PubMed、ScienceDirect、Springer Link 和 Google Scholar 4 个数据库，共有 10 项研究参与荟萃分析。ReviewManager (RevMan) 5.4 软件用于对符合条件的研究进行荟萃分析。在隐性模型中发现 OXTR rs53576 与抑郁症之间存在显着相关性（比值比 (OR) AA 与 AG + GG = 1.28，95% 置信区间 (CI) [1.02–1.59]，P = 0.03），而与其他两种遗传模型没有关联（显性模型：OR AA + AG vs. GG = 1.01，95% CI [0.87–1.18]，P = 0.87；等位基因模型：OR A vs. G = 0.95，95% CI [ 0.83–1.09]，P = 0.46）。在白种人人群中观察到显着相关性（OR 1.29，95% CI [1.01, 1.64]，P = 0.04），而亚洲人群则没有显示显着相关性（OR 1.22，95% CI [0.71, 2.09]，P = 0.48）。这项荟萃分析是迄今为止首次对 OXTR rs53576 多态性与抑郁症的关联进行全面调查，其结果反映了目前文献中可获得的数据，可以作为进一步研究的指南。