Objective: To investigate the pharmacological effects and molecular mechanisms of lanthanum hydroxide(LH) on ectopic mineralization of soft tissue and abnormal bone in rats with acute kidney injury(AKI). Methods: Wistar rats were modeled by 5/6 nephrectomy. After the operation, the rats were divided into different groups, the biochemical indexes of serum collected at different times. LH was administered by intragastric tube at doses of 0.4, 0.2, and 0.1g/kg, respectively. Rats were sacrificed in the 16th week after LH treatment. Observation of pathological changes in tissues were made by specific staining. Western Blot, Real-Time Quantitative PCR, and immunohistochemistry techniques were used to detect the impact on pathway-related proteins. Results: Compared with the control group (no LH administered), the serum phosphate level of the LH group was significantly reduced (p

中文翻译：

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氢氧化镧与慢性肾病矿物质和骨骼疾病：大鼠模型

目的：探讨氢氧化镧（LH）对急性肾损伤（AKI）大鼠软组织异位矿化和骨异常的药理作用及分子机制。方法：采用5/6肾切除术建立Wistar大鼠模型。术后将大鼠分为不同组，采集不同时间的血清生化指标。 LH通过胃管注射，剂量分别为0.4、0.2和0.1g/kg。 LH治疗后第16周处死大鼠。通过特异性染色观察组织病理变化。使用蛋白质印迹、实时定量PCR和免疫组织化学技术来检测对通路相关蛋白的影响。结果：与对照组（未给予LH）相比，LH组血清磷酸盐水平显着降低（p