In this research, the synthesis, fabrication steps and characterization of a new modified glassy carbon electrode (GCE) with CuFe₂O₄ magnetic nanoparticles combined with zeolitic imidazolate framework (ZIF-8) embedded graphene quantum dots (GQDs), (CuFe₂O₄/ZIF-8@GQDs), for electrodetermination of the imatinib (IMB), anti-cancer drug, are reported. The synthesized nanocomposite was characterized using X-ray powder diffraction (XRD), energy dispersive X-ray spectroscopy (EDX) and field emission scanning electron microscopy (FE-SEM). The GCE modified with CuFe₂O₄/ZIF-8@GQDs nanocomposite shows high electrocatalytic activity toward the oxidation of IMB compared with the bare GCE, GQDs/GCE, ZIF-8@GQDs/GCE, CuFe₂O₄/GCE and CuFe₂O₄@GQDs/GCE. The resulted electrocatalytic activity of the CuFe₂O₄/ZIF-8@GQDs/GCE can be attributed to the synergistic effect of the outstanding magnetic, electrical properties of the CuFe₂O₄/ZIF-8@GQDs and high conductivity of GQDs, as well as the high electron transport rate of the nanocomposite. Under optimized conditions, the developed sensor, CuFe₂O₄/ZIF-8@GQDs/GCE, has static properties such as wide linear range responses (0.02–11.85 and 11.85–94.20 μM), low detection limit (1.2 nM), high sensitivity (5.655 μA μM⁻¹), long-term signal stability and reproducibility (RSD = 2.23%). It should be noted that the CuFe₂O₄/ZIF-8@GQDs/GCE sensor could be used for determination of IMB in biological and pharmaceutical samples, indicating its feasibility for real analysis.

_{在本研究中，采用CuFe 2} O ₄磁性纳米颗粒与沸石咪唑酯骨架（ZIF-8）嵌入石墨烯量子点（GQD）相结合的新型改性玻碳电极（GCE）的合成、制造步骤和表征， （CuFe ₂ O ₄ /ZIF-8@GQDs），用于抗癌药物伊马替尼（IMB）的电测定。使用X射线粉末衍射（XRD）、能量色散X射线光谱（EDX）和场发射扫描电子显微镜（FE-SEM）对合成的纳米复合材料进行了表征。与裸GCE、GQDs/GCE、ZIF-8@GQDs/GCE、CuFe 2 O 4 /GCE和CuFe相比，CuFe 2 O 4 /ZIF-8@GQDs纳米复合_材料修饰_的GCE对_IMB的氧化表现出较高的电催化活性₂ O ₄ @GQDs/GCE。_{CuFe 2} O ₄ /ZIF-8@GQDs/GCE的电催化活性可归因于 CuFe ₂ O ₄ /ZIF-8@GQDs 优异的磁、电性能和 GQDs 高电导率的协同效应，以及纳米复合材料的高电子传输速率。在优化条件下，所开发的传感器CuFe ₂ O ₄ /ZIF-8@GQDs/GCE具有静态特性，例如宽线性范围响应（0.02–11.85和11.85–94.20 μM）、低检测限（1.2 nM）、高灵敏度 (5.655 μA μM ⁻¹ )、长期信号稳定性和重现性 (RSD = 2.23%)。值得注意的是，CuFe ₂ O ₄ /ZIF-8@GQDs/GCE传感器可用于生物和药物样品中IMB的测定，表明其实际分析的可行性。