OBJECTIVE Rates of daily cannabis use and cannabis use disorder (CUD) are increasing in the United States. Prominent addiction theories suggest that stress potentiation of drug cue incentive salience is a central feature of disordered versus recreational drug use, which has been corroborated using a neurophysiological index of drug cue incentive salience (i.e., the late positive potential [LPP]) in adults who regularly use cannabis. However, the mechanism through which acute stress potentiates the cannabis LPP in CUD is unclear. METHOD To address this gap, cannabis LPPs were measured before and after a stress induction in 95 adults who regularly use cannabis. Physiological (hypothalamic-pituitary-adrenal [HPA] axis, heart rate, skin conductance) and subjective stress reactivity were also measured. RESULTS Based on prior work, we hypothesized that cortisol stress reactivity would predict poststress cannabis LPP enhancement in more severe CUD. The hypothesis was supported and specific to HPA-axis versus autonomic or subjective stress reactivity. CONCLUSIONS Acute stress potentiation of the cannabis LPP, likely via HPA-axis activation, may be a biomarker of heavy/disordered cannabis use in adults who regularly use cannabis. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

中文翻译：

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大麻使用障碍中神经药物提示反应性的生理应激调节。

目标 在美国，每日使用大麻和大麻使用障碍 (CUD) 的比例正在增加。突出的成瘾理论表明，药物提示激励显着性的压力增强是紊乱性药物与娱乐性药物使用的一个核心特征，这一点已通过成人药物提示激励显着性的神经生理学指数（即晚期正电位 [LPP]）得到证实。经常使用大麻。然而，急性应激增强 CUD 中大麻 LPP 的机制尚不清楚。方法 为了解决这一差距，对 95 名经常使用大麻的成年人进行压力诱导前后的大麻 LPP 测量。还测量了生理（下丘脑-垂体-肾上腺 [HPA] 轴、心率、皮肤电导）和主观应激反应性。结果根据之前的工作，我们假设皮质醇应激反应性可以预测更严重的 CUD 中应激后大麻 LPP 的增强。该假设得到支持，并且特定于 HPA 轴与自主或主观应激反应性。结论 大麻 LPP 的急性应激增强（可能通过 HPA 轴激活）可能是经常使用大麻的成年人重度/无序使用大麻的生物标志物。（PsycInfo 数据库记录 (c) 2023 APA，保留所有权利）。