BACKGROUND Enlarged perivascular spaces (EPVS) of the brain may be involved in dementia, such as Alzheimer's disease and cerebral small vessel disease (CSVD). Hypertension has been reported to be a risk factor for dementia and CSVD, but the association between blood pressure (BP) and perivascular spaces is still unclear. The aim of this study was to determine the association between BP and EPVS volumes and to examine the interactions of relevant factors. METHODS A total of 9296 community-dwelling subjects aged ≥65 years participated in a brain magnetic resonance imaging and health status screening examination. Perivascular volume was measured using a software package based on deep learning that was developed in-house. The associations between BP and EPVS volumes were examined by analysis of covariance and multiple regression analysis. RESULTS Mean EPVS volumes increased significantly with rising systolic and diastolic BP levels (P for trend = .003, P for trend<.001, respectively). In addition, mean EPVS volumes increased significantly for every 1-mmHg-increment in systolic and diastolic BPs (both P values <.001). These significant associations were still observed in the sensitivity analysis after excluding subjects with dementia. CONCLUSIONS The present data suggest that higher systolic and diastolic BP levels are associated with greater EPVS volumes in cognitively normal older people.

中文翻译：

---

居住在社区的日本老年人的晚年高血压和壳核区域扩大的血管周围空间。

背景技术大脑血管周围空间扩大(EPVS)可能与痴呆有关，例如阿尔茨海默氏病和脑小血管病(CSVD)。据报道，高血压是痴呆和脑小血管病的危险因素，但血压 (BP) 与血管周围间隙之间的关系仍不清楚。本研究的目的是确定血压和 EPVS 容量之间的关联并检查相关因素的相互作用。方法对9296名年龄≥65岁的社区居民参加脑磁共振成像和健康状况筛查检查。使用内部开发的基于深度学习的软件包测量血管周围体积。通过协方差分析和多元回归分析来检查 BP 和 EPVS 体积之间的关联。结果 平均 EPVS 体积随着收缩压和舒张压水平的升高而显着增加（趋势 P 分别 = .003，趋势 P<.001）。此外，收缩压和舒张压每增加 1 mmHg，平均 EPVS 体积就会显着增加（P 值均<.001）。在排除痴呆症受试者后，在敏感性分析中仍然观察到这些显着的关联。结论 目前的数据表明，认知正常的老年人中较高的收缩压和舒张压水平与较大的 EPVS 体积相关。