INTRODUCTION Sympathetic nervous system disorder promotes atrial fibrillation (AF), and neuropeptide Y (NPY) is an important neurotransmitter. This study aimed to explore the predictive value of plasma NPY in patients with AF. METHODS Five hundred seventy-six patients were divided into the AF (including paroxysmal and persistent AF; 360) and sinus rhythm (SR) groups (216). NPY level was detected using enzyme-linked immunosorbent assay (ELISA), and NPY mRNA expression level was detected using q-PCR. Logistic regression was used to analyse the risk factors of AF; the correlation between blood NPY level and age, body mass index (BMI), left ventricular ejection fraction (LVEF), left atrial diameter (LAD), European Heart rate Association (EHRA) score in patients with AF. ROC curve was utilised to predict AF. RESULTS Plasma NPY levels were found to be higher in patients with AF than in patients with SR and in patients with persistent AF than in patients with paroxysmal AF; Blood NPY mRNA levels were higher in the paroxysmal and persistent AF groups compared to the SR group (P < 0.05). Increased age [OR^ = 1.201 (95% CI: 1.01, 1.427)] and high NPY [OR^ = 1.239 (95% CI: 1.022, 1.501)] were factors found to affect AF detrimentally. NPY was associated with BMI (r = 0.5856, P < 0.05), LAD (r = 0.4023, p < 0.05) and EHRA score (r = 0.898, P < 0.05). The ROC curve for the predictive value of plasma NPY levels for AF showed an AUC value of 0.919 (P < 0.05), while for persistent AF was also shown with an AUC of 0.784 (P < 0.05). CONCLUSION Circulating NPY may be a promising molecular biomarker of AF.

中文翻译：

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循环神经肽 Y 可能是诊断心房颤动的生物标志物。

引言交感神经系统紊乱可促进心房颤动（AF），而神经肽Y（NPY）是一种重要的神经递质。本研究旨在探讨血浆NPY对AF患者的预测价值。方法 将 576 例患者分为 AF（包括阵发性和持续性 AF；360 例）和窦性心律（SR）组（216 例）。采用酶联免疫吸附试验（ELISA）检测NPY水平，采用q-PCR检测NPY mRNA表达水平。采用Logistic回归分析AF的危险因素；AF患者血NPY水平与年龄、体重指数(BMI)、左心室射血分数(LVEF)、左心房内径(LAD)、欧洲心率协会(EHRA)评分的相关性。ROC曲线用于预测AF。结果 AF 患者血浆 NPY 水平高于 SR 患者，持续性 AF 患者高于阵发性 AF 患者；阵发性和持续性 AF 组的血液 NPY mRNA 水平高于 SR 组（P < 0.05）。年龄增加 [OR^ = 1.201 (95% CI: 1.01, 1.427)] 和高 NPY [OR^ = 1.239 (95% CI: 1.022, 1.501)] 是对 AF 产生不利影响的因素。NPY 与 BMI（r = 0.5856，P < 0.05）、LAD（r = 0.4023，p < 0.05）和 EHRA 评分（r = 0.898，P < 0.05）相关。血浆 NPY 水平对 AF 的预测价值的 ROC 曲线显示，AUC 值为 0.919（P < 0.05），而对于持续性 AF，AUC 值为 0.784（P < 0.05）。结论 循环 NPY 可能是 AF 的一个有前途的分子生物标志物。