N-Phthalimidoaziridines were synthesized from 3,5-disubstituted 1,2,4-oxadiazoles containing alkenyl and pyridine fragments. N-Phthalimidoaziridines were heated in the presence of N-arylmaleimide to give the corresponding N-phthalimidopyrrolidines. The synthesized N-phthalimidoaziridines and N-phthalimidopyrrolidines contain several pharmacophoric groups (the aziridine, oxadiazole, pyridine, and phthalimide moieties) making them potential active ingredients of medicines.

中文翻译：

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基于5-烯基-1,2,4-恶二唑的N-邻苯二甲酰亚氨基氮丙啶热解合成八氢吡咯并[3,4-c]吡咯

N-邻苯二甲酰亚氨基氮丙啶由含有烯基和吡啶片段的3,5-二取代1,2,4-恶二唑合成。N-邻苯二甲酰亚氨基氮丙啶在N-芳基马来酰亚胺存在下加热，得到相应的N-邻苯二甲酰亚胺吡咯烷。合成的N-邻苯二甲酰亚胺氮丙啶和N-邻苯二甲酰亚胺吡咯烷含有多个药效基团（氮丙啶、恶二唑、吡啶和邻苯二甲酰亚胺部分），使其成为药物的潜在活性成分。