Purpose of Review

According to the World Health Organization (WHO), cardiovascular disease is the leading cause of death worldwide. Heart failure has been defined as a global pandemic leading to millions of deaths. Recent research clearly approved the beneficial effect of Coenzyme Q10 supplementation in treatment and prevention of cardiovascular disease in patients with heart failure in clinical trials but did not distinguish between the oxidised form CoQ10 and reduced form CoQH2 of Coenzyme Q10. The aim of this study is to determine differences in medical application of CoQ10 and CoQH2 supplementation and evaluate the efficacy of CoQ10 and CoQH2 supplementation to prevent cardiovascular disease in patients with heart failure.

Recent Findings

A PubMed search for the terms “ubiquinone” and “ubiquinol” was conducted, and 28 clinical trials were included. Our findings go along with the biochemical description of CoQ10 and CoQH2, recording cardiovascular benefits for CoQ10 and antioxidative and anti-inflammatory properties for CoQH2. Our main outcomes are the following: (I) CoQ10 supplementation reduced cardiovascular death in patients with heart failure. This is not reported for CoQH2. (II) Test concentrations leading to cardiovascular benefits are much lower in CoQ10 studies than in CoQH2 studies. (III) Positive long-term effects reducing cardiovascular mortality are only observed in CoQ10 studies.

Summary

Based on the existing literature, the authors recommend CoQ10 instead of CoQH2 to treat and prevent cardiovascular disease in patients with heart failure.

中文翻译：

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辅酶 Q10（泛醌）和还原型辅酶 Q10（泛醇）作为补充剂预防心血管疾病和降低心血管死亡率的比较

审查目的

据世界卫生组织（WHO）称，心血管疾病是全世界死亡的主要原因。心力衰竭被定义为导致数百万人死亡的全球流行病。最近的研究在临床试验中明确证实了补充辅酶 Q10 对治疗和预防心力衰竭患者心血管疾病的有益作用，但没有区分辅酶 Q10 的氧化型 CoQ10 和还原型 CoQH2。本研究的目的是确定辅酶 Q10 和辅酶 QH2 补充剂在医学应用中的差异，并评估辅酶 Q10 和辅酶 QH2 补充剂预防心力衰竭患者心血管疾病的功效。

最近的发现

对术语“泛醌”和“泛醇”进行了 PubMed 搜索，纳入了 28 项临床试验。我们的研究结果与 CoQ10 和 CoQH2 的生化描述相一致，记录了 CoQ10 对心血管的益处以及 CoQH2 的抗氧化和抗炎特性。我们的主要结果如下： (I) 补充 CoQ10 可减少心力衰竭患者的心血管死亡。没有关于 CoQH2 的报道。(II) CoQ10 研究中导致心血管益处的测试浓度比 CoQH2 研究中低得多。(III) 降低心血管死亡率的积极长期作用仅在 CoQ10 研究中观察到。

概括

根据现有文献，作者推荐CoQ10代替CoQH2来治疗和预防心力衰竭患者的心血管疾病。